399275
Nω-Hydroxy-nor-L-arginine diacetate Salt
≥97% (TLC), Arginase inhibitor, solid
別名:
Nω-Hydroxy-nor-L-arginine, Diacetate Salt, nor-NOHA, 2CH3CO2H, L-2-Amino-(4-(2ʹ-hydroxyguanidino)butyric Acid, 2CH3CO2H
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この商品について
実験式（ヒル表記法）:
C5H12N4O3 · 2C2H4O2
CAS番号:
分子量:
296.28
MDL number:
UNSPSC Code:
12352209
NACRES:
NA.77
Assay:
≥97% (TLC)
Form:
solid
Storage condition:
OK to freeze, desiccated (hygroscopic)
製品名
Nω-Hydroxy-nor-L-arginine, Diacetate Salt, A potent, selective, competitive, and high affinity inhibitor of arginase.
Quality Segment
assay
≥97% (TLC)
form
solid
potency
2 μM IC50
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic)
color
off-white
solubility
water: 50 mg/mL
shipped in
ambient
storage temp.
−20°C
SMILES string
N(O)\C(=N\CC[C@H](N)C(=O)O)\N.OC(=O)C.OC(=O)C
InChI key
PQFYTZJPYBMTCT-QTNFYWBSSA-N
General description
A potent, selective, competitive, and high affinity inhibitor of arginase. Shown to inhibit arginase from rat liver (IC50 = 2 µM) and mouse macrophages (IC50 = 50 µM). Shown to specifically interact with the manganese-cluster of the enzyme active site. Does not function as a substrate or as an inhibitor for NOS. Hence, nor-NOHA may be a useful tool to study the interplays between arginase and NOS.
Biochem/physiol Actions
Primary Target
arginase from rat liver
arginase from rat liver
Secondary Target
mouse macrophages (IC₅₀ = 50 µM)
mouse macrophages (IC₅₀ = 50 µM)
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Gobert, A.P., et al. 2000. Infect. Immun. 68, 4653.
Meurs, H., et al. 2000. Br. J. Pharmacol. 130, 1793.
Moali, C., et al. 2000. Biochemistry 39, 8208.
Tenu, J.P. et al. 1999. Nitric Oxide 3, 427.
Moali, C., et al. 1998. Biochemistry 37, 10453.
Custot, J., et al. 1997. J. Am. Chem. Soc. 119, 4086.
Meurs, H., et al. 2000. Br. J. Pharmacol. 130, 1793.
Moali, C., et al. 2000. Biochemistry 39, 8208.
Tenu, J.P. et al. 1999. Nitric Oxide 3, 427.
Moali, C., et al. 1998. Biochemistry 37, 10453.
Custot, J., et al. 1997. J. Am. Chem. Soc. 119, 4086.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
保管分類
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable