400011
Caspase-1 Inhibitor I, Cell-Permeable
The Caspase-1 Inhibitor I, Cell-Permeable controls the biological activity of Caspase-1. This small molecule/inhibitor is primarily used for Cancer applications.
別名:
Caspase-1 Inhibitor I, Cell-Permeable, ICE Inhibitor I, Cell-permeable, YVAD-CHO, Cell-permeable, Ac-AAVALLPAVLLALLAPYVAD-CHO
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この商品について
実験式（ヒル表記法）:
C97H160N20O24
分子量:
1990.43
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥97% (HPLC)
Form:
solid
Storage condition:
OK to freeze
Quality Segment
assay
≥97% (HPLC)
form
solid
potency
1 nM Ki
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white
solubility
DMSO: 5 mg/mL
shipped in
ambient
storage temp.
−20°C
General description
A cell-permeable inhibitor of caspase-1 (ICE; Interleukin-1β Converting Enzyme), caspase-4, and caspase-5. The C-terminal YVAD-CHO sequence of this peptide is a highly specific, potent, and reversible inhibitor of caspase-1 (Ki = 1 nM). The N-terminal sequence (amino acid residues 1-16) corresponds to the hydrophobic region (h-region) of the signal peptide of the Kaposi fibroblast growth factor (K-FGF) and confers cell-permeability to the peptide.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
Caspase-1
Caspase-1
Product does not compete with ATP.
Reversible: yes
Preparation Note
Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Other Notes
Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Tyr-Val-Ala-Asp-CHO
Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
Hilbi, H., et al. 1998. J. Biol. Chem. 273, 32895.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Lin, Y.-Z., et al. 1996. J. Biol. Chem.271, 5305.
Lin, Y.-Z., et al. 1995. J. Biol. Chem.270, 14255.
Reiter, L.A. 1994. Int. J. Pept. Protein Res.43, 87.
Thornberry, N.A., et al. 1994. Biochemistry33, 3934.
Thornberry, N.A., et al. 1994. MethodsEnzymol. 244, 615.
Thornberry, N.A., et al. 1992. Nature 356, 768.
Hilbi, H., et al. 1998. J. Biol. Chem. 273, 32895.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Lin, Y.-Z., et al. 1996. J. Biol. Chem.271, 5305.
Lin, Y.-Z., et al. 1995. J. Biol. Chem.270, 14255.
Reiter, L.A. 1994. Int. J. Pept. Protein Res.43, 87.
Thornberry, N.A., et al. 1994. Biochemistry33, 3934.
Thornberry, N.A., et al. 1994. MethodsEnzymol. 244, 615.
Thornberry, N.A., et al. 1992. Nature 356, 768.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
保管分類
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable