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405268

Indomethacin

Name: Indomethacin
Brand: MM

≥98% (HPLC), powder, COX inhibitor, Calbiochem

別名:

Indomethacin, 1-( p-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic Acid, 1-(p-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic Acid

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この商品について

実験式（ヒル表記法）:

C₁₉H₁₆ClNO₄

CAS番号:

53-86-1

分子量:

357.79

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD00057095

Assay:

≥98% (by assay)

Form:

powder

Storage condition:

OK to freeze

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特性

製品名

Indomethacin, A non-steroidal anti-inflammatory, cell permeable, antipyretic agent.

Quality Segment

100

description

Merck USA index - 14, 4968

assay

≥98% (by assay)

form

powder

potency

740 nM IC₅₀

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze

color

white to off-white

solubility

ethanol: 20 mg/mL

shipped in

ambient

storage temp.

10-30°C

SMILES string

Clc1ccc(cc1)C(=O)[n]2c3c(c(c2C)CC(=O)O)cc(cc3)OC

InChI

1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23)

InChI key

CGIGDMFJXJATDK-UHFFFAOYSA-N

詳細

General description

A cell-permeable, non-steroidal anti-inflammatory, anti-pyretic agent. Non-selective cyclooxygenase (COX) inhibitor (IC₅₀ = 740 nM for COX-1; IC₅₀ = 970 nM for COX-2). Inhibits phospholipase A₂ (IC₅₀ = 145 µM). Reported to reduce Aβ₄₂ levels independently of COX activity.

A non-steroidal anti-inflammatory, cell permeable, antipyretic agent. Non-selective COX inhibitor (IC₅₀ = 740 nM for COX-1; IC₅₀ = 970 nM for COX-2). Inhibits phospholipase A₂(IC₅₀ = 145 µM). Strongly inhibits insoluble transthyretin (TTR) amyloid fibril formation and suppresses production of Aβ-peptide and secreted form of APP by inhibition of APP mRNA levels in NG108-15 cells.

Biochem/physiol Actions

Cell permeable: yes

Product does not compete with ATP.

Reversible: no

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Kodoyama, K., et al. 2001. Biochem. Biophys. Res. Commun.281, 483.
Weggen, S., et al. 2001. Nature414, 212.
Kalgutkar, A.S., et al. 2000. Proc. Natl. Acad. Sci. USA97, 925.
Klabunde, T., et al. 2000. Nat. Struct. Biol.7, 312.
Futaki, N., et al. 1994. Prostaglandins47, 55.
Futaki, N., et al. 1994. Prostaglandins47, 55.
Stevenson, K.M., and Lumbers, E.R. 1992. J. Dev. Physiol. 17, 257.
Oliw, E. 1980. Prostaglandins19, 271.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Highly Toxic & Carcinogenic / Teratogenic (I)

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pictograms

GHS06

signalword

Danger

hcodes

H300

pcodes

P264 - P270 - P301 + P310 - P405 - P501

Hazard Classifications

Acute Tox. 1 Oral

保管分類

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c