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420136

JNK Inhibitor IX

Name: JNK Inhibitor IX
Brand: MM

≥95% (HPLC), JNK2 and JNK3 inhibitor, solid

別名:

JNK Inhibitor IX, N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-1-naphthamide

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この商品について

実験式（ヒル表記法）:

C₂₀H₁₆N₂OS · xH₂O

CAS番号:

312917-14-9

分子量:

332.42 (anhydrous basis)

MDL number:

MFCD01005305

UNSPSC Code:

12352200

NACRES:

NA.77

Assay:

≥95% (HPLC)

Form:

solid

Storage condition:

OK to freeze, protect from light

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特性

製品名

JNK Inhibitor IX, The JNK Inhibitor IX, also referenced under CAS 312917-14-9, controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Quality Segment

100

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

tan

solubility

DMSO: 10 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

[s]1c2c(c(c1NC(=O)c3c4c(ccc3)cccc4)C#N)CCCC2

InChI

1S/C20H16N2OS/c21-12-17-15-9-3-4-11-18(15)24-20(17)22-19(23)16-10-5-7-13-6-1-2-8-14(13)16/h1-2,5-8,10H,3-4,9,11H2,(H,22,23)

InChI key

WQGDQGAFSDMBLA-UHFFFAOYSA-N

詳細

General description

A thienylnaphthamide compound that acts as a potent and ATP binding site-targeting inhibitor of JNK2 and JNK3 (pIC₅₀ = 6.5 and 6.7, respectively) with little or no activity against JNK1, p38α, and a panel of more than 30 other kinases (pIC₅₀<5.0). In contrast, SP600125 offers little selectivity between JNK1 and JNK3 (pIC₅₀ = 6.4 and 5.9, respectively) under the same assay conditions.

Biochem/physiol Actions

Cell permeable: no

Primary Target
JNK2 and JNK3

Product competes with ATP.

Reversible: no

pIC50 = 6.5 and 6.7, against JNK2 and JNK3, respectively

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Angell, R.M., et al. 2007. Bioorg. Med. Chem. Lett.17, 1296.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)

保管分類

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c