422712
KN-93
InSolution
別名:
InSolution KN-93
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この商品について
実験式（ヒル表記法）:
C26H29ClN2O4S
CAS番号:
分子量:
501.04
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥95% (HPLC)
Form:
liquid
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light
Quality Segment
assay
≥95% (HPLC)
form
liquid
potency
370 nM Ki
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
shipped in
wet ice
storage temp.
−20°C
SMILES string
[S](=O)(=O)(N(CCO)c2c(cccc2)CN(C\C=C\c3ccc(cc3)Cl)C)c1ccc(cc1)OC
InChI
1S/C26H29ClN2O4S/c1-28(17-5-6-21-9-11-23(27)12-10-21)20-22-7-3-4-8-26(22)29(18-19-30)34(31,32)25-15-13-24(33-2)14-16-25/h3-16,30H,17-20H2,1-2H3/b6-5+
InChI key
LLLQTDSSHZREGW-AATRIKPKSA-N
General description
A cell-permeable, competitive inhibitor of Ca2+/calmodulin-dependent protein kinase II (Ki = 370 nM). Selectively binds to the Calmodulin (CaM) binding site of the enzyme and prevents the association of CaM with CaM Kinase II. Inhibits glucose-induced and forskolin-stimulated insulin release from isolated pancreatic islets. Has no significant effect on protein kinase A activity. Induces G1 cell cycle arrest and apoptosis in NIH 3T3 cells.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
cam kinase 2
cam kinase 2
Product does not compete with ATP.
Reversible: yes
Packaging
Packaged under inert gas
Physical form
A 5 mM (1 mg/399 µl) solution of KN-93 (Cat. No. 422708) in DMSO.
Preparation Note
Following initial thaw aliquot and freeze (-20°C).
Other Notes
Fan, G.H., et al. 1999. Mol. Pharmacol.56, 39.
Tombes, R.M., et al. 1995. Cell Growth Differentiation6, 1063.
Chen, C., et al. 1994. Science266, 291.
Mamiya, N., et al. 1993. Biochem. Biophys. Res. Commun.195, 608.
Niki, I., et al. 1993. Biochem. Biophys. Res. Commun.191, 255.
Sumi, M., et al. 1991. Biochem. Biophys. Res. Commun.181, 968.
Tokumitsu, H., et al. 1990. J. Biol. Chem.265, 4315.
Tombes, R.M., et al. 1995. Cell Growth Differentiation6, 1063.
Chen, C., et al. 1994. Science266, 291.
Mamiya, N., et al. 1993. Biochem. Biophys. Res. Commun.195, 608.
Niki, I., et al. 1993. Biochem. Biophys. Res. Commun.191, 255.
Sumi, M., et al. 1991. Biochem. Biophys. Res. Commun.181, 968.
Tokumitsu, H., et al. 1990. J. Biol. Chem.265, 4315.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Irritant (B)
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保管分類
10 - Combustible liquids
一体何が起きているの？
WGK 2
引火点 (F)
188.6 °F - closed cup - (Dimethylsulfoxide)
引火点（°C）
87 °C - closed cup - (Dimethylsulfoxide)
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Group 4: Flammable liquids + Type 3 petroleums + Hazardous rank III + Water insoluble liquid
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