427218
FX11
≥96% (HPLC), solid, lactate dehydrogenase A inhibitor, Calbiochem®
別名:
Lactate Dehydrogenase A Inhibitor, FX11
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この商品について
実験式（ヒル表記法）:
C22H22O4
CAS番号:
分子量:
350.41
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.54
Assay:
≥96% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
製品名
Lactate Dehydrogenase A Inhibitor, FX11, Lactate Dehydrogenase A Inhibitor, FX11, CAS 213971-34-7, is a cell permeable, selective, reversible, NADH competitive inhibitor of lactate dehhydrogenase A (LDHA; Ki = 8 µM for human liver LDHA).
Quality Segment
assay
≥96% (HPLC)
form
solid
potency
8 μM Ki
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
DMSO: 50 mg/mL
shipped in
ambient
storage temp.
2-8°C
General description
A cell permeable, gossypol analog that acts as a selective, reversible, and NADH competitive inhibitor of lactate dehhydrogenase A (LDHA; Ki = 8 µM for human liver LDHA). Does not affect the activities of LDHB and glyceraldehyde-3-phosphate dehydrogenase even at higher concentrations. Shown to increase oxygen consumption, reactive oxygen species production, and cell death in P493 human lymphoma B cells. Also shown to reduce mitochondrial transmembrane potential and ATP levels and increase AMP kinase activity. Exhibits synergistic toxicity in P493 cells when combined with FK866 (Cat. No. 481908). Blocks the progression of human lymphoma and pancreatic cancer xenografts and when used in combination with FK866 it induces lymphoma regression.
Application
Lactate Dehydrogenase A Inhibitor, FX11, CAS 213971-34-7, is a cell permeable, selective, reversible, NADH competitive inhibitor of lactate dehhydrogenase A (LDHA; Ki = 8 µM for human liver LDHA).
Biochem/physiol Actions
Cell permeable: yes
Primary Target
LDHA
LDHA
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Le, A., et al. 2011. Proc Natl Acad Sci USA.107, 2037.
Deck, L. M., et al. 1998. J Med Chem.41, 3879.
Deck, L. M., et al. 1998. J Med Chem.41, 3879.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
保管分類
11 - Combustible Solids
一体何が起きているの？
WGK 3
引火点 (F)
Not applicable
引火点（°C）
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
427218-10MG:
jan