440025
Luteolin
≥90% (HPLC), antioxidant flavonoid, solid
別名:
Luteolin, 3ʹ,4ʹ,5,7-Tetrahydroxyflavone
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この商品について
Assay:
≥90% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
製品名
Luteolin, An antioxidant flavonoid and a free radical scavenger.
Quality Segment
description
Merck USA index - 14, 5614
assay
≥90% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
yellow
solubility
aqueous base: 1.4 mg/mL, DMSO: 7 mg/mL, ethanol: soluble
shipped in
ambient
storage temp.
2-8°C
SMILES string
[o]1c2c([c](cc1c3cc(c(cc3)O)O)=O)c(cc(c2)O)O
InChI
1S/C15H10O6/c16-8-4-11(19)15-12(20)6-13(21-14(15)5-8)7-1-2-9(17)10(18)3-7/h1-6,16-19H
InChI key
IQPNAANSBPBGFQ-UHFFFAOYSA-N
General description
An antioxidant flavonoid and a free radical scavenger. Inhibits rat liver cytosolic glutathione S-transferase activity. Also shows cytotoxic effects on Raji lymphoma cells. Incubation of the non-tumor cell line C3H10T½CL8 with luteolin results in induction of p53 accumulation and apoptosis, with apoptosis occurring at the G2/M phase of the cell cycle. Also shown to inhibit TPL2 kinase.
Biochem/physiol Actions
Cell permeable: no
Primary Target
rat liver cytosolic glutathione S-transferase activity
rat liver cytosolic glutathione S-transferase activity
Product does not compete with ATP.
Reversible: no
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 weeks at -20°C.
Other Notes
Kim, J.E., et al. 2011. J. Pharmacol. Exp. Ther.in press.
Korkina, L.G., and Afanasev, I.B. 1997. Adv. Pharmacol.38, 151.
Plaumann, B., et al. 1996. Oncogene 13, 1605.
Ramanathan, R., et al. 1994. Free Radic. Biol. Med.16, 43.
Shimoi, L., et al. 1994. Carcinogenesis15, 2669.
Korkina, L.G., and Afanasev, I.B. 1997. Adv. Pharmacol.38, 151.
Plaumann, B., et al. 1996. Oncogene 13, 1605.
Ramanathan, R., et al. 1994. Free Radic. Biol. Med.16, 43.
Shimoi, L., et al. 1994. Carcinogenesis15, 2669.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
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保管分類
11 - Combustible Solids
一体何が起きているの？
WGK 3
引火点 (F)
Not applicable
引火点（°C）
Not applicable