472804
S-Methyl-L-thiocitrulline, Dihydrochloride
A cell-permeable inhibitor of nitric oxide synthase that exhibits about 17-fold greater selectivity for rat neuronal nitric oxide synthase (IC50 = 300 nM) compared to the endothelial enzyme (IC50 = 5.4 µM).
別名:
S-Methyl-L-thiocitrulline, Dihydrochloride, N δ-(S-Methyl)isothioureido-L-ornithine, Nδ-(S-Methyl)isothioureido-L-ornithine
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この商品について
実験式（ヒル表記法）:
C7H15N3O2S · 2HCl
CAS番号:
分子量:
278.20
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥95% (HPLC)
Form:
solid
Storage condition:
OK to freeze, desiccated (hygroscopic)
Quality Segment
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic)
color
white to off-white
solubility
water: 50 mg/mL
shipped in
ambient
storage temp.
2-8°C
SMILES string
S(C)\C(=N/CCC[C@H]([N+H3])C(=O)[O-])\N
InChI
1S/C7H15N3O2S/c1-13-7(9)10-4-2-3-5(8)6(11)12/h5H,2-4,8H2,1H3,(H2,9,10)(H,11,12)/t5-/m0/s1
InChI key
NGVMVBQRKZPFLB-YFKPBYRVSA-N
General description
A cell-permeable inhibitor of nitric oxide synthase that exhibits about 17-fold greater selectivity for rat neuronal nitric oxide synthase (IC50 = 300 nM) compared to the endothelial enzyme (IC50 = 5.4 µM).
A cell-permeable, inhibitor of nitric oxide synthase that exhibits about 17-fold greater selectivity for rat neuronal nitric oxide synthase (IC50 = 300 nM) compared to the endothelial enzyme (IC50 = 5.4 µM).
Biochem/physiol Actions
Reversible: no
Target IC50: 300 nM for rat neuronal nitric oxide synthase
Cell permeable: yes
Primary Target
Rat neuronal nitric oxide synthase
Rat neuronal nitric oxide synthase
Product does not compete with ATP.
Packaging
Packaged under inert gas
Other Notes
Krishnaswamy, N., et al. 1995. J. Biol. Chem.270, 11103.
Furfine, E.S., et al. 1994. J. Biol. Chem. 269, 26677.
Narayanan, K., and Griffith, O.W. 1994. J. Med. Chem.37, 885.
Furfine, E.S., et al. 1994. J. Biol. Chem. 269, 26677.
Narayanan, K., and Griffith, O.W. 1994. J. Med. Chem.37, 885.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
保管分類
11 - Combustible Solids
wgk
WGK 3
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。