475863
MK2a Inhibitor
The MK2a Inhibitor, also referenced under CAS 41179-33-3, controls the biological activity of MK2a. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
別名:
MK2a Inhibitor, Mitogen-activated protein kinase-activated protein kinase 2a Inhibitor, 4-(2ʹ-Fluorobiphenyl-4-yl)-N-(4-hydroxyphenyl)-butyramide, CMPD1, MAPKAPK2a Inhibitor
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この商品について
実験式（ヒル表記法）:
C22H20FNO2
CAS番号:
分子量:
349.40
MDL number:
UNSPSC Code:
12352202
NACRES:
NA.77
Assay:
≥95% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
Quality Segment
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
pale yellow
solubility
DMSO: 5 mg/mL, ethanol: 5 mg/mL
shipped in
ambient
storage temp.
2-8°C
SMILES string
Fc1c(cccc1)c2ccc(cc2)CCCC(=O)Nc3ccc(cc3)O
InChI
1S/C22H20FNO2/c23-21-6-2-1-5-20(21)17-10-8-16(9-11-17)4-3-7-22(26)24-18-12-14-19(25)15-13-18/h1-2,5-6,8-15,25H,3-4,7H2,(H,24,26)
InChI key
ODYAQBDIXCVKAE-UHFFFAOYSA-N
General description
A non-ATP-competitive, reversible, selective inhibitor of p38α-mediated MK2a (mitogen-activated protein kinase-activated protein kinase 2a) phosphorylation (Kiapp = 330 nM). Does not inhibit p38α-mediated phosphorylation of the the other two known p38 substrates, MBP and ATF-2.
A reversible p-amidophenolic compound that selectively inhibits the phosphorylation of MK2a (mitogen-activated protein kinase-activated protein kinase 2a; Kiapp = 330 nM) by p38α in a non-ATP-competitive manner. Does not block the kinase activity of p38α towards the other two known p38 substrates, MBP and ATF-2.
Biochem/physiol Actions
Cell permeable: no
Kiapp = 330 nM against mitogen-activated protein kinase-activated protein kinase 2a (MK2a)
Primary Target
Mk2α
Mk2α
Product does not compete with ATP.
Reversible: yes
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Davidson, W., et al. 2004. Biochemistry43, 11658.
Lukas, S.M., et al. 2004. Biochemistry43, 9950.
Lukas, S.M., et al. 2004. Biochemistry43, 9950.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
保管分類
11 - Combustible Solids
wgk
WGK 1