495620
Olomoucine
A purine derivative that acts as a potent, reversible and selective inhibitor of p34cdk1/cyclin B and related kinases.
別名:
Olomoucine
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この商品について
実験式（ヒル表記法）:
C15H18N6O
CAS番号:
分子量:
298.34
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (TLC)
Form:
crystalline solid
Storage condition:
OK to freeze
Quality Segment
assay
≥98% (TLC)
form
crystalline solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
solubility
DMSO: soluble
shipped in
ambient
storage temp.
−20°C
SMILES string
[n]1(c2nc(nc(c2nc1)NCc3ccccc3)NCCO)C
InChI
1S/C15H18N6O/c1-21-10-18-12-13(17-9-11-5-3-2-4-6-11)19-15(16-7-8-22)20-14(12)21/h2-6,10,22H,7-9H2,1H3,(H2,16,17,19,20)
InChI key
GTVPOLSIJWJJNY-UHFFFAOYSA-N
General description
A purine derivative that acts as a potent, reversible and selective inhibitor of p34cdk1/cyclin B (IC50 = 7 µM) and related kinases including p33cdk2/cyclin A (IC50 = 7 µM), p33cdk2/cyclin E (IC50 = 7 µM), p33cdk5/p35 (IC50 = 3 µM), and p44 MAP kinase (IC50 = 25 µM). Acts by competing for the ATP binding domain of the kinase. Exhibits reduced sensitivity towards related kinases, p34cdk4/cyclin D (IC50 >1 mM), and p40cdk6/cyclin D3 (IC50 >250 µM). Does not significantly affect the activity of other protein kinases at 1 mM. Known to inhibit DNA synthesis in interleukin-2-stimulated T lymphocytes and trigger G1 arrest similar to that observed in interleukin-2-deprived cells. Also used to synchronize cells in G1. A 50 mM (5 mg/336 µl) solution of Olomoucine (Cat. No. 495624) in DMSOis also available.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
p34cdk1/cyclin B
p34cdk1/cyclin B
Product competes with ATP.
Reversible: yes
Target IC50: 7 µM, 7 µM, 7 µM, 3 µM, 25 µM against p34cdk1/cyclin B, p33cdk2/cyclin A, p33cdk2/cyclin E, p33cdk5/p35, and p44 MAP kinase, respectively
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 6 months at -20°C.
Other Notes
Abraham, R.T., et al. 1995. Biol. Cell 83, 105.
Mistelli, T., and Warren, G. 1995. J. Cell Sci. 108, 2715.
Glab, N., et al. 1994. FEBS Lett. 353, 207.
Veselý, J., et al. 1994. Eur. J. Biochem.224, 771.
Mistelli, T., and Warren, G. 1995. J. Cell Sci. 108, 2715.
Glab, N., et al. 1994. FEBS Lett. 353, 207.
Veselý, J., et al. 1994. Eur. J. Biochem.224, 771.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
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保管分類
11 - Combustible Solids
一体何が起きているの？
WGK 3
引火点 (F)
Not applicable
引火点（°C）
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
495620-1MG: + 495620-5MG: + 495620-VMG:
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