5.06271
Ketanserin Tartrate
別名:
Ketanserin Tartrate, 5-HT 2A Serotonin Receptor Antagonist, Ketanserin, R 41 468
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この商品について
実験式（ヒル表記法）:
C22H22FN3O3 · xC4H6O6
CAS番号:
分子量:
395.43 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥97% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
assay
≥97% (HPLC)
Quality Segment
form
solid
potency
1.49 nM Ki
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
DMSO: soluble
storage temp.
2-8°C
SMILES string
Fc1ccc(cc1)C(=O)C2CCN(CC2)CCN3C(=O)Nc4c(cccc4)C3=O.OC(C(O)C(=O)O)C(=O)O.O
InChI
1S/C22H22FN3O3.C4H6O6.H2O/c23-17-7-5-15(6-8-17)20(27)16-9-11-25(12-10-16)13-14-26-21(28)18-3-1-2-4-19(18)24-22(26)29;5-1(3(7)8)2(6)4(9)10;/h1-8,16H,9-14H2,(H,24,29);1-2,5-6H,(H,7,8)(H,9,10);1H2
InChI key
KJJRKCWDAHTVRL-UHFFFAOYSA-N
General description
A selective 5-HT2A serotonin receptor antagonist with weak adrenergic receptor blocking properties. Strong affinity for 5-HT2AR (Ki = 1.49 nM) relative to other family members like 5-HT2BR (Ki = 740 nM) and 5-HT2CR (Ki = 59 nM). Often used in conjunction with SB 206553 to distinguish 5-HT2AR and 5-HT2CR activity.
Biochem/physiol Actions
Primary Target
5-HT2A
5-HT2A
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Ros, R. et al. 2013. PNAS.110, 348.
Knight, A. R. et al. 2004. Naunyn Schmiedebergs Arch. Pharmacol.370, 114.
Aloyo, V. J. and Harvey, J. A. 2000. Eur. J. Pharmacol.406, 163.
Leysen, J. E. et al. 1981. Life Sci.28, 1015.
Knight, A. R. et al. 2004. Naunyn Schmiedebergs Arch. Pharmacol.370, 114.
Aloyo, V. J. and Harvey, J. A. 2000. Eur. J. Pharmacol.406, 163.
Leysen, J. E. et al. 1981. Life Sci.28, 1015.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Toxic (F)
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
保管分類
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects