5.06272
SB 206553 Hydrochloride
別名:
SB 206553 Hydrochloride, 5-HT 2C Serotonin Receptor Antagonist, SB 206553, 5-HT 2B Serotonin Receptor Antagonist, SB 206553, SB206553, SB-206553
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この商品について
実験式（ヒル表記法）:
C17H16N4O · xHCl
CAS番号:
分子量:
292.34 (free base basis)
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥99% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
assay
≥99% (HPLC)
Quality Segment
form
solid
potency
3.2 nM Ki
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
yellow
solubility
DMSO: soluble
storage temp.
2-8°C
SMILES string
[n]1(c2c(cc3c(c2)CCN3C(=O)Nc4cnccc4)cc1)C
InChI
1S/C17H16N4O/c1-20-7-4-12-10-16-13(9-15(12)20)5-8-21(16)17(22)19-14-3-2-6-18-11-14/h2-4,6-7,9-11H,5,8H2,1H3,(H,19,22)
InChI key
QJQORSLQNXDVGE-UHFFFAOYSA-N
General description
A selective 5-HT2C serotonin receptor inhibitor with lesser affinity for 5-HT2BR. Often used in conjunction with ketanserin to distinguish 5-HT2AR and 5-HT2CR activity. SB206553 has highest affinity for 5-HT2CR (Ki = 3.2nM) and less for 5-HT2BR (Ki = 5.5 nM) and 5-HT2AR (Ki = 2,300 nM).
Biochem/physiol Actions
Primary Target
5-HT2C
5-HT2C
Secondary Target
5-HT2B
5-HT2B
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Ros, R. et al. 2013. PNAS.110, 348.
Knight, A. R. et al. 2004. Naunyn Schmiedebergs Arch. Pharmacol.370, 114.
Cussac, D. et al. 2002. Naunyn Schmiedebergs Arch. Pharmacol.365, 242.
Knight, A. R. et al. 2004. Naunyn Schmiedebergs Arch. Pharmacol.370, 114.
Cussac, D. et al. 2002. Naunyn Schmiedebergs Arch. Pharmacol.365, 242.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable