主要文書

すべての文書を表示

5.06272

SB 206553 Hydrochloride

Name: SB 206553 Hydrochloride
Brand: MM

別名:

SB 206553 Hydrochloride, 5-HT _2C Serotonin Receptor Antagonist, SB 206553, 5-HT _2B Serotonin Receptor Antagonist, SB 206553, SB206553, SB-206553

ログインで組織・契約価格をご覧ください。

サイズを選択してください

表示を変更する

この商品について

実験式（ヒル表記法）:

C₁₇H₁₆N₄O · xHCl

CAS番号:

158942-04-2

分子量:

292.34 (free base basis)

MDL number:

MFCD00928314

UNSPSC Code:

12352200

NACRES:

NA.77

eCl@ss:

32150312

Assay:

≥99% (HPLC)

Form:

solid

Storage condition:

OK to freeze, protect from light

テクニカルサービス

お困りのことがあれば、経験豊富なテクニカルサービスチームがお客様をサポートします。

お手伝いします

特性

assay

≥99% (HPLC)

Quality Segment

100

form

solid

potency

3.2 nM K_i

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

yellow

solubility

DMSO: soluble

storage temp.

2-8°C

SMILES string

[n]1(c2c(cc3c(c2)CCN3C(=O)Nc4cnccc4)cc1)C

InChI

1S/C17H16N4O/c1-20-7-4-12-10-16-13(9-15(12)20)5-8-21(16)17(22)19-14-3-2-6-18-11-14/h2-4,6-7,9-11H,5,8H2,1H3,(H,19,22)

InChI key

QJQORSLQNXDVGE-UHFFFAOYSA-N

詳細

General description

A selective 5-HT_2C serotonin receptor inhibitor with lesser affinity for 5-HT_2BR. Often used in conjunction with ketanserin to distinguish 5-HT_2AR and 5-HT_2CR activity. SB206553 has highest affinity for 5-HT_2CR (K_i = 3.2nM) and less for 5-HT_2BR (K_i = 5.5 nM) and 5-HT_2AR (K_i = 2,300 nM).

Biochem/physiol Actions

Primary Target
5-HT_2C

Secondary Target
5-HT_2B

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Ros, R. et al. 2013. PNAS.110, 348.

Knight, A. R. et al. 2004. Naunyn Schmiedebergs Arch. Pharmacol.370, 114.
Cussac, D. et al. 2002. Naunyn Schmiedebergs Arch. Pharmacol.365, 242.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

保管分類

11 - Combustible Solids

WGK

WGK 3

引火点 (F)

Not applicable

引火点（°C）