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5.08227

Paclitaxel

Name: Paclitaxel
Brand: MM

InSolution, ≥97%, 25 mM in DMSO, from Taxus sp.

別名:

InSolution Paclitaxel, Taxus sp., TAXOL^® InSolution, Baccatin III N-benzyl-β-phenylisoserine Ester

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この商品について

実験式（ヒル表記法）:

C₄₇H₅₁NO₁₄

CAS番号:

33069-62-4

分子量:

853.91

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD00869953

Assay:

≥97% (HPLC)

Form:

liquid

Quality level:

100

Storage condition:

OK to freeze, avoid repeated freeze/thaw cycles, desiccated (hygroscopic), protect from light

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特性

製品名

Paclitaxel, Taxus sp., InSolution, ≥97%, 25 mM in DMSO

Quality Level

100

assay

≥97% (HPLC)

form

liquid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, avoid repeated freeze/thaw cycles, desiccated (hygroscopic), protect from light

storage temp.

−70°C

SMILES string

N([C@H]([C@@H](O)C(=O)O[C@H]3C[C@]4([C@H](C6[C@]7([C@H](OC7)C[C@@H]([C@]6(C(=O)[C@@H](C(=C3C)C4(C)C)OC(=O)C)C)O)OC(=O)C)OC(=O)c5ccccc5)O)c2ccccc2)C(=O)c1ccccc1

InChI

1S/C47H51NO14/c1-25-31(60-43(56)36(52)35(28-16-10-7-11-17-28)48-41(54)29-18-12-8-13-19-29)23-47(57)40(61-42(55)30-20-14-9-15-21-30)38-45(6,32(51)22-33-46(38,24-58-33)62-27(3)50)39(53)37(59-26(2)49)34(25)44(47,4)5/h7-21,31-33,35-38,40,51-52,57H,22-24H2,1-6H3,(H,48,54)/t31-,32-,33+,35-,36+,37+,38?,40-,45+,46-,47+/m0/s1

InChI key

RCINICONZNJXQF-VAZQATRQSA-N

詳細

General description

Paclitaxel, a microtubule-stabilizing agent, is a tricyclic diterpenoid characterized by a “taxane” complex ring and an amide group, which sometimes leads to its classification as a pseudo alkaloid. Its mechanism of action involves selectively disrupting microtubule dynamics, resulting in mitotic arrest and subsequent cell death. Paclitaxel demonstrates antineoplastic properties with a wide range of antitumor activity. As a chemotherapeutic agent, it selectively binds to the β-subunit of tubulin proteins, facilitating their polymerization and assembly, which stabilizes microtubule formation. This stabilization creates a dysfunctional mitotic spindle, leading to significant mitotic arrest during the G2/M phase and ultimately causing cell death via an apoptosis pathway.

Application

Paclitaxel has been used to study fibronectin type III domain-containing protein 5 (FNDC5)-mediated paclitaxel sensitivity in non-small cell lung cancer (NSCLC) cells.

Biochem/physiol Actions

Cell permeable: yes

Reversible: yes

Packaging

Packaged under inert gas

Physical form

A 25 mM (10 mg/468 µL) sterile-filtered solution of Paclitaxel, Taxus sp. (Cat. No. 580555) in DMSO.

Other Notes

Derry, W.B., et al. 1995. Biochemistry34, 2203.
Milas, L., et al. 1995. Cancer Chemother. Pharmacol.35, 297.
Donaldson, K.L., et al. 1994. Int. J. Cancer57, 847.
Hornback, N.B., et al. 1994. In Vivo8, 819.
Manthey, C.L., et al. 1992. J. Immunol.149, 2459.
Rowinsky, E.K., et al. 1992. Semin. Oncol. 19, 646.
Ding, A.H., et al. 1990. Science248, 370.
Mogensen, M.M. and Tucker, J.B. 1990. J. Cell Sci.97, 101.
Slichenmeyer, W.J. and Von Hoff, D.D. 1990. J. Clin. Pharmacol.30, 770.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Taxol is a registered trademark of Bristol-Myers Squibb Co.

Disclaimer

Toxicity: Standard Handling (A)

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pictograms

GHS08

signalword

Danger

pcodes

P202 - P260 - P280 - P308 + P313 - P405 - P501

Hazard Classifications

Muta. 2 - Repr. 1B - STOT RE 2

wgk

WGK 2

flash_point_f

188.6 °F

flash_point_c

87 °C

target_organs

Central nervous system,Bone marrow,Cardio-vascular system

hcodes

H341,H360FD,H373

保管分類

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

Substances Subject to be Indicated Names

ishl_indicated

Substances Subject to be Notified Names

ishl_notified

5082270001:

jan

Group 4: Flammable liquids + Type 3 petroleums + Hazardous rank III + Water insoluble liquid

fsl

試験成績書（COA）

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