5.09890
Benztropine
別名:
Benztropine, Benzatropine, Cogentin
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この商品について
実験式（ヒル表記法）:
C21H2NO · xCH4O3S
CAS番号:
分子量:
284.25 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
assay
≥98% (HPLC)
Quality Segment
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
storage temp.
2-8°C
SMILES string
[S](=O)(=O)(O)C.N1([C@@H]2CC[C@@H]1CC(C2)OC(c4ccccc4)c3ccccc3)C
InChI
1S/C21H25NO.CH4O3S/c1-22-18-12-13-19(22)15-20(14-18)23-21(16-8-4-2-5-9-16)17-10-6-3-7-11-17;1-5(2,3)4/h2-11,18-21H,12-15H2,1H3;1H3,(H,2,3,4)/t18-,19-;/m1./s1
InChI key
CPFJLLXFNPCTDW-STYNFMPRSA-N
General description
A brain penetrating azabicyclo[3.2.1]octane derivative with anti-cholinergic and anti-histaminergic properties. Acts as an antagonist of muscarinic M1 and M3 receptors induces robust differentiation of oligodendrocytes precursor cell differentiation (OPC; EC50 = 500 nM) and promotes myelination. Reduces the expression of Notch 1 in immature OPC and reduces the levels of cyclin D1 and D2 and c-Fos and c-Jun indicating its inhibitory effect on cell cycle progression. Shown to reduce the severity of the acute phase of multiple sclerosis and virtually eliminates the relapse phase in animal models. Significantly reduces the severity in the experimental autoimmune encephalomyelitis (EAE) model of relapsing-remitting multiple sclerosis when administered alone or co-administered with FTY720 (Cat. No. 344597).
Biochem/physiol Actions
Cell permeable: yes
Primary Target
Muscarinic M1/M3
Muscarinic M1/M3
Reversible: yes
Packaging
Packaged under inert gas
Other Notes
Deshmukh, V.A, et al. 2013. Nature 502,327.
Doshay, L.J., et al. 1956. J Am Med Assoc.162, 1031.
Doshay, L.J., et al. 1956. J Am Med Assoc.162, 1031.
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Toxic (F)
注意喚起語
Danger
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 4 Oral
一体何が起きているの？
WGK 3
引火点 (F)
Not applicable
引火点（°C）
Not applicable
ハザードコード
保管分類
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects