517301
P-Glycoprotein Inhibitor, C-4
The P-Glycoprotein Inhibitor, C-4 controls the biological activity of P-Glycoprotein. This small molecule/inhibitor is primarily used for Cancer applications.
別名:
P-Glycoprotein Inhibitor, C-4, (E)-4-Chloro-N-(3-(3-(4-hydroxy-3-methoxyphenyl)acryloyl)phenyl)benzamide, C-4
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この商品について
実験式（ヒル表記法）:
C23H18ClNO4
CAS番号:
分子量:
407.85
UNSPSC Code:
12352202
NACRES:
NA.77
PubChem Substance ID:
Assay:
≥95% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
Quality Segment
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
yellow
solubility
DMSO: 10 mg/mL
shipped in
ambient
storage temp.
2-8°C
SMILES string
COC1=C(C=CC(=C1)C=CC(=O)C2=CC(=CC=C2)NC(=O)C3=CC=C(C=C3)Cl)O
InChI
1S/C23H18ClNO4/c1-29-22-13-15(6-12-21(22)27)5-11-20(26)17-3-2-4-19(14-17)25-23(28)16-7-9-18(24)10-8-16/h2-14,27H,1H3,(H,25,28)
InChI key
SFYVLZRWJCFMTJ-UHFFFAOYSA-N
General description
A cell-permeable cinnamoyl compound that reversibly inhibits P-gp (P-glycoprotein) efflux function and reverses the MDR (multidrug resistance) phenotype with no noticeable effect on P-gp expression. Shown to significantly enhance Paclitaxel- (Cat. No. 580555) and Vincristine- (Cat. No. 677181) induced cytotoxicity as well as apoptosis in P-gp expressing KBV20C cells.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
P-Glycoprotein
P-Glycoprotein
Product does not compete with ATP.
Reversible: yes
Packaging
Packaged under inert gas
Other Notes
Kim, Y.K., et al. 2007. Biochem. Biophys. Res. Commun.355, 136.
Woo, H.B., et al. 2005. Bioorg. Med. Chem. Lett.15, 3782.
Woo, H.B., et al. 2005. Bioorg. Med. Chem. Lett.15, 3782.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
保管分類
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable