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517301

P-Glycoprotein Inhibitor, C-4

Name: P-Glycoprotein Inhibitor, C-4
Brand: MM

The P-Glycoprotein Inhibitor, C-4 controls the biological activity of P-Glycoprotein. This small molecule/inhibitor is primarily used for Cancer applications.

別名:

P-Glycoprotein Inhibitor, C-4, (E)-4-Chloro-N-(3-(3-(4-hydroxy-3-methoxyphenyl)acryloyl)phenyl)benzamide, C-4

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この商品について

実験式（ヒル表記法）:

C₂₃H₁₈ClNO₄

CAS番号:

864426-22-2

分子量:

407.85

UNSPSC Code:

12352202

NACRES:

NA.77

PubChem Substance ID:

16062976

Assay:

≥95% (HPLC)

Form:

solid

Storage condition:

OK to freeze, protect from light

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特性

Quality Segment

100

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

yellow

solubility

DMSO: 10 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

COC1=C(C=CC(=C1)C=CC(=O)C2=CC(=CC=C2)NC(=O)C3=CC=C(C=C3)Cl)O

InChI

1S/C23H18ClNO4/c1-29-22-13-15(6-12-21(22)27)5-11-20(26)17-3-2-4-19(14-17)25-23(28)16-7-9-18(24)10-8-16/h2-14,27H,1H3,(H,25,28)

InChI key

SFYVLZRWJCFMTJ-UHFFFAOYSA-N

詳細

General description

A cell-permeable cinnamoyl compound that reversibly inhibits P-gp (P-glycoprotein) efflux function and reverses the MDR (multidrug resistance) phenotype with no noticeable effect on P-gp expression. Shown to significantly enhance Paclitaxel- (Cat. No. 580555) and Vincristine- (Cat. No. 677181) induced cytotoxicity as well as apoptosis in P-gp expressing KBV20C cells.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
P-Glycoprotein

Product does not compete with ATP.

Reversible: yes

Packaging

Packaged under inert gas

Other Notes

Kim, Y.K., et al. 2007. Biochem. Biophys. Res. Commun.355, 136.
Woo, H.B., et al. 2005. Bioorg. Med. Chem. Lett.15, 3782.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

保管分類

11 - Combustible Solids

一体何が起きているの？

WGK 2

引火点 (F)

Not applicable

引火点（°C）