520219
PPACK II trifluoroacetate salt
≥95% (HPLC), solid, kallikrein inhibitor, Calbiochem®
別名:
PPACK II, Trifluoroacetate Salt
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この商品について
実験式（ヒル表記法）:
C25H33ClN6O3 · 2C2HF3O2
CAS番号:
分子量:
729.07
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥95% (HPLC)
Form:
solid
Storage condition:
OK to freeze, desiccated
製品名
PPACK II, Trifluoroacetate Salt, Potent and specific irreversible inhibitor of plasma and glandular kallikreins.
Quality Segment
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated
color
off-white
solubility
water: 100 mg/mL
shipped in
ambient
storage temp.
2-8°C
SMILES string
ClCC(=O)[C@@H](N[C@@H](Cc2ccccc2)C(=O)NC(=O)[C@H](N)Cc1ccccc1)CCCNC(=N)N
InChI
1S/C25H33ClN6O3/c26-16-22(33)20(12-7-13-30-25(28)29)31-21(15-18-10-5-2-6-11-18)24(35)32-23(34)19(27)14-17-8-3-1-4-9-17/h1-6,8-11,19-21,31H,7,12-16,27H2,(H4,28,29,30)(H,32,34,35)/t19-,20+,21+/m1/s1
InChI key
UFXAQJOOAQICNE-HKBOAZHASA-N
General description
Potent and specific irreversible inhibitor of plasma and glandular kallikreins. Inhibits the cleavage of atrial naturiuretic peptide (ANP 1-126) by kallikreins. Also inhibits adrenal kininogenase, a kallikrein-like enzyme. Also available as a 10 mM solution in H2O.
Biochem/physiol Actions
Cell permeable: no
Primary Target
Plasma and glandular kallikreins
Plasma and glandular kallikreins
Product does not compete with ATP.
Reversible: no
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
Other Notes
Byrne, R.E., and Scanu, A.M. 1989. J. Lipid Res. 30, 109.
Scicli, G., et al. 1989. Adv. Exp. Med. Biol.247B, 217.
Gibson, T.R., et al. 1987. Endocrinology120, 764.
Kettner, G., and Shaw, E. 1981. Methods Enzymol.80, 826.
Scicli, G., et al. 1989. Adv. Exp. Med. Biol.247B, 217.
Gibson, T.R., et al. 1987. Endocrinology120, 764.
Kettner, G., and Shaw, E. 1981. Methods Enzymol.80, 826.
H-D-Phe-Phe-Arg-chloromethylketone, 2TFA
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
保管分類
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。