5.30748
SRT1720 HCl
InSolution
別名:
InSolution SRT1720, HCl, N-(2-(3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl)phenyl)-2-quinolinecarboxamide, 4HCl;, Histone Acetyltransferase Inhibitor XI, p300/CBP Inhibitor IX, SRT1720, HCl InSolution, HAT Inhibitor XI, SIRT3 Inhibitor II, Sirtuin-3 In
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この商品について
Assay:
≥98% (HPLC)
Form:
liquid
Storage condition:
OK to freeze, avoid repeated freeze/thaw cycles, desiccated (hygroscopic), protect from light
Quality Segment
assay
≥98% (HPLC)
form
liquid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, avoid repeated freeze/thaw cycles, desiccated (hygroscopic), protect from light
storage temp.
−70°C
SMILES string
[s]1c2[n](c(c1)CN6CCNCC6)cc(n2)c3c(cccc3)NC(=O)c4nc5c(nc4)cccc5.Cl
InChI
1S/C25H23N7OS.ClH/c33-24(22-13-27-20-7-3-4-8-21(20)28-22)29-19-6-2-1-5-18(19)23-15-32-17(16-34-25(32)30-23)14-31-11-9-26-10-12-31;/h1-8,13,15-16,26H,9-12,14H2,(H,29,33);1H
InChI key
DTGRRMPPXCRRIM-UHFFFAOYSA-N
General description
An enhanced aqueous soluble version of SRT1720 (Cat. No. 567860 ).
Please note that the molecular weight for this compound is batch-specific due to variable water content.
Please note that the molecular weight for this compound is batch-specific due to variable water content.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
SIRT3
SIRT3
Reversible: yes
Secondary Target
p300 HAT
p300 HAT
Packaging
Packaged under inert gas
Physical form
A 25 mM (10 mg/650 µl) sterile-filtered solution of SRT1720, HCl (Cat. No. 567860 ) in DMSO.
Preparation Note
Following initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.
Other Notes
Baur, J.A., et al. 2012. Nat. Rev. Drug Discov.11, 443.
Minor, R.K., et al. 2011. Sci. Rep.1, 70.
Huber, J.L., et al. 2010. Future Med. Chem.2, 1751.
Pacholec, M., et al. 2010. J. Biol. Chem.285, 8340.
Jin, L., et al. 2009. Protein Sci.18, 514.
Feige, J.N., et al. 2008. Cell Metab.8, 347.
Milne, J.C., et al. 2007. Nature450, 712.
Minor, R.K., et al. 2011. Sci. Rep.1, 70.
Huber, J.L., et al. 2010. Future Med. Chem.2, 1751.
Pacholec, M., et al. 2010. J. Biol. Chem.285, 8340.
Jin, L., et al. 2009. Protein Sci.18, 514.
Feige, J.N., et al. 2008. Cell Metab.8, 347.
Milne, J.C., et al. 2007. Nature450, 712.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
保管分類
10 - Combustible liquids
wgk
WGK 3
flash_point_f
188.6 °F
flash_point_c
87 °C