主要文書

すべての文書を表示

540213

PTP Inhibitor V, PHPS1

Name: PTP Inhibitor V, PHPS1
Brand: MM

The PTP Inhibitor V, PHPS1, also referenced under CAS 314291-83-3, controls the biological activity of PTP. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

別名:

PTP Inhibitor V, PHPS1, 4-(Nʹ-(3-(4-Nitrophenyl)-5-oxo-1-phenyl-1,5-dihydro-pyrazol-(4Z)-ylidene)-hydrazino)-benzenesulfonic acid, PhenylHydrazonoPyrazolone Sulfonate 1, PTPNN1 Inhibitor, EC-PTP/PCPTP1 Inhibitor I, MptpA Inhibitor, PTP-SL, PhenylHydrazonoPyrazolone Sulfonate 1, PTPNN1 Inhibitor, 4-(Nʹ-(3-(4-Nitrophenyl)-5-oxo-1-phenyl-1,5-dihydro-pyrazol-(4Z)-ylidene)-hydrazino)-benzenesulfonic acid, EC-PTP/PCPTP1 Inhibitor I, MptpA Inhibitor, PTP-SL Inhibitor I, PTP1B Inhibitor V, SHP1 Inhibitor VI, SHP2 Inhibitor III

で組織・契約価格をご覧ください。

サイズを選択してください

表示を変更する

この商品について

実験式（ヒル表記法）:

C₂₁H₁₅N₅O₆S

CAS番号:

314291-83-3

分子量:

465.44

MDL number:

MFCD00004468

NACRES:

NA.28

UNSPSC Code:

12352200

Assay:

≥95% (HPLC)

Form:

solid

Storage condition:

OK to freeze, desiccated (hygroscopic), protect from light

テクニカルサービス

お困りのことがあれば、経験豊富なテクニカルサービスチームがお客様をサポートします。

お手伝いします

特性

Quality Segment

100

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

color

reddish

solubility

DMSO: 10 mg/mL

shipped in

ambient

storage temp.

2-8°C

詳細

General description

A cell-permeable phosphotyrosine mimetic that acts as a reversible, active-site targeting, substrate-competitive inhibitor of Shp-2 (IC₅₀ and K_i = 2.1 and 0.73 µM, respectively). PHPS1 inhibits ECPTP, PTP1B, Shp1, mycobacterium MptpA only at higher concentrations (IC₅₀ = 5.4, 19, 30, and 39 µM, respectively) and exhibits little activity against PTPH1, STEP, PTPN7, PTPRK, GLEPP1, or LAR2 even at concentrations as high as 50 µM. Shown to inhibit Shp-2-dependent cellular signaling and tumor cell colonies formation.

Packaging

Packaged under inert gas

Other Notes

Hellmuth, K., et al. 2008. Proc. Natl. Acad. Sci. USA105, 7275.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

保管分類

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c