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548000

1-Pyrrolidinecarbodithioic Acid, Ammonium Salt

Name: 1-Pyrrolidinecarbodithioic Acid, Ammonium Salt
Brand: MM

Cell permeable. Inhibits the induction of NOS activity in rat alveolar macrophages. Prevents apoptosis in human HL-60 cells and thymocytes, but induces apoptosis in human and rat smooth muscle cells.

別名:

1-Pyrrolidinecarbodithioic Acid, Ammonium Salt, APDC, Ammonium Pyrrolidinedithiocarbamate, PDTC, NH₄

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この商品について

実験式（ヒル表記法）:

C₅H₁₂N₂S₂

CAS番号:

5108-96-3

分子量:

164.29

UNSPSC Code:

12352106

NACRES:

NA.77

MDL number:

MFCD00012720

Assay:

≥98% (titration)

Form:

solid

Storage condition:

OK to freeze, desiccated (hygroscopic)

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特性

Quality Segment

100

assay

≥98% (titration)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, desiccated (hygroscopic)

color

white

solubility

water: 1 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

[S-]C(=S)N1CCCC1.[N+H4]

InChI

1S/C5H9NS2.H3N/c7-5(8)6-3-1-2-4-6;/h1-4H2,(H,7,8);1H3

InChI key

MDDIUTVUBYEEEM-UHFFFAOYSA-N

詳細

General description

Cell permeable. Inhibits the induction of nitric oxide synthase activity in rat alveolar macrophages. Prevents apoptosis in human HL-60 cells and thymocytes, but induces apoptosis in human and rat smooth muscle cells. Inhibits NF-κB activation and HIV replication in lymphocytes.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
Induction of nitric oxide synthase activity in rat alveolar macrophages

Product does not compete with ATP.

Reversible: no

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 3 months at -20°C.

From Catalog:

Desc. Field- added "cell-permeable"

Other Notes

Tsai, J.C., et al. 1996. J. Biol. Chem.271, 3667.
Pan, Z., et al. 1995. J. Biol. Chem.270, 7787.
Bessho, R., et al. 1994. Biochem. Pharmacol.48, 1883.
Sherman, M.P., et al. 1993. Biochem. Biophys. Res. Commun.191, 1301.
Schreck, R., et al. 1992. J. Exp. Med.175, 1181.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)

保管分類

11 - Combustible Solids

一体何が起きているの？

WGK 3

引火点 (F)

Not applicable

引火点（°C）