565773
γ-Secretase Inhibitor XII
The γ-Secretase Inhibitor XII controls the biological activity of γ-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.
別名:
γ-Secretase Inhibitor XII, Z-IL-CHO
ログインで組織・契約価格をご覧ください。
サイズを選択してください
表示を変更する
この商品について
実験式（ヒル表記法）:
C20H30N2O4
分子量:
362.46
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥95% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
Quality Segment
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
DMSO: 5 mg/mL
shipped in
ambient
storage temp.
−20°C
General description
A cell-permeable, reversible dipeptide aldehyde that reduces Aβ production by blocking γ-secretase activity in vitro (Aβ40 IC50 = 7.9 µM; Aβ42 IC50 = 7.6 µM) and in cultured CHO 2b-7 cells that stably overexpress APP695 (Aβ40 IC50 = 11.5 µM; Aβ42 IC50 = 8.3 µM). Also blocks the generation of CTFγ (γ-secretase-generated carboxyl-terminal fragment). Does not affect the formation of amyloid-β-precursor protein (APP).
Biochem/physiol Actions
Cell permeable: yes
Primary Target
Aβ40 in vitro
Aβ40 in vitro
Product does not compete with ATP.
Reversible: yes
Target IC50: 7.9 µM for Aβ40; 7.6 µM for Aβ42 in vitro
Packaging
Packaged under inert gas
Other Notes
Weijzen, S., et al. 2002. Nat. Med.8, 979.
McLendon, C., et al. 2000. FASEB J.14, 2383.
McLendon, C., et al. 2000. FASEB J.14, 2383.
Z-Ile-Leu-CHO
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
保管分類
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable