ログインで組織・契約価格をご覧ください。
サイズを選択してください
表示を変更する
この商品について
実験式(ヒル表記法):
C19H11N3Na2O7S2
CAS番号:
分子量:
503.42
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.54
Assay:
≥97% (HPLC)
Form:
solid
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light
製品名
SHP1/2 PTPase Inhibitor, NSC-87877, The SHP1/2 PTPase Inhibitor, NSC-87877, also referenced under CAS 56932-43-5, controls the biological activity of SHP1/2 PTPase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
Quality Segment
assay
≥97% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
color
red-brown
solubility
water: 10 mg/mL
shipped in
ambient
storage temp.
2-8°C
SMILES string
[Na+].[Na+].[S](=O)(=O)([O-])c1cc2c(cc(cc2)N\N=C3/C=C(c4c(nccc4)C/3=O)[S](=O)(=O)[O-])cc1
InChI
1S/C19H13N3O7S2.2Na/c23-19-16(10-17(31(27,28)29)15-2-1-7-20-18(15)19)22-21-13-5-3-12-9-14(30(24,25)26)6-4-11(12)8-13;;/h1-10,21H,(H,24,25,26)(H,27,28,29);;/q;2*+1/p-2/b22-16+;;
InChI key
YOGRUDWAJPVHEL-LLDDCTHSSA-L
General description
A cell-permeable 7-aza-8-hydroxyquinoline compound that acts as a potent, catalytic site-targeting inhibitor of SHP-1 and SHP-2 protein tyrosine phosphatases (IC50 = 355 nM and 318 nM, respectively). It inhibits PTP1B and HePTP with less potency (IC50 = 1.69 µM and 7.75 µM, respectively) and exhibits >200-fold selectivity over DEP1, CD45, and LAR. Shown to inhibit both basal and stimulated SHP-2 activity in HEK293 cells.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
SHP1/2 PTPase
SHP1/2 PTPase
Product does not compete with ATP.
Reversible: no
Target IC50: 355 nM and 318 nM against SHP-1 and SHP-2 protein tyrosine phosphatases, respectively
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Chen, L., et al. 2006. Mol. Pharmacol.70, 562.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
保管分類
11 - Combustible Solids
一体何が起きているの?
WGK 2
引火点 (F)
Not applicable
引火点(°C)
Not applicable