574713
Syk Inhibitor III
The Syk Inhibitor III, also referenced under CAS 1485-00-3, controls the biological activity of Syk. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
別名:
Syk Inhibitor III, 3,4-Methylenedioxy-β-nitrostyrene
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この商品について
Assay:
≥98% (GC)
Form:
solid
Storage condition:
OK to freeze, protect from light
description
RTECS - WL5270000
Quality Segment
assay
≥98% (GC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
yellow to brown
solubility
DMSO: 25 mg/mL (Use only fresh DMSO.)
shipped in
ambient
storage temp.
−20°C
SMILES string
[N+](=O)([O-])\C=C/c1cc2c(cc1)OCO2
InChI
1S/C9H7NO4/c11-10(12)4-3-7-1-2-8-9(5-7)14-6-13-8/h1-5H,6H2/b4-3-
InChI key
KFLWBZPSJQPRDD-ARJAWSKDSA-N
General description
A cell-permeable nitrostyrene compound that acts as a selective inhibitor of Syk kinase activity (IC50 = 2.5 µM). It inhibits Src only at much higher concentrations (IC50 = 29.3 µM) and exhibits little effect against Fak and JAK2. Shown to potently inhibit platelet aggregation induced by various stimulators, including U46619, ADP, arachidonic acid, collagen, thrombin, ionophore A23187, and PDBu (IC50 ranges from 2.1 to 25.9 µM).
Biochem/physiol Actions
Cell permeable: yes
Primary Target
Syk
Syk
Product does not compete with ATP.
Reversible: no
Target IC50: 2.5 µM against Syk kinase activity
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Wang, W.Y., et al. 2006. Mol. Pharmacol.70, 1380.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Irritant (B)
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2
保管分類
11 - Combustible Solids