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580553

(±)-Taxifolin hydrate

Name: (±)-Taxifolin hydrate
Brand: MM

An antioxidant flavonoid that scavenges superoxide (1.5 x 10⁵ M⁻¹ s⁻¹) and suppresses the cytotoxicity of superoxide and hydrogen peroxide in Chinese hamster V79 cells.

Synonym(s):

3,3′,4′,5,7-Pentahydroxydihydroflavone Hydrate, Dihydroquercetin Hydrate, 3,3′,4′,5,7-Pentahydroxyflavanone hydrate, Dihydroquercetin hydrate

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About This Item

Empirical Formula (Hill Notation):

C₁₅H₁₂O₇ · xH₂O

CAS Number:

24198-97-8

Molecular Weight:

304.25 (anhydrous basis)

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD11044454

Assay:

≥95% (HPLC)

Form:

solid

Storage condition:

OK to freeze, protect from light

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Properties

Quality Segment

100

description

RTECS - LK6920000

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

white to off-white

solubility

ethanol: 20 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

O.O[C@@H]1[C@H](Oc2cc(O)cc(O)c2C1=O)c3ccc(O)c(O)c3

InChI

1S/C15H12O7.H2O/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6;/h1-5,14-19,21H;1H2/t14-,15+;/m0./s1

InChI key

DNQPGSVMBPSRIR-LDXVYITESA-N

Description

General description

An antioxidant flavonoid that suppresses the cytotoxicity of superoxide ions and hydrogen peroxide in Chinese hamster V79 cells.

An antioxidant flavonoid that scavenges superoxide (1.5 x 10⁵ M^-1 s^-1) and suppresses the cytotoxicity of superoxide and hydrogen peroxide in Chinese hamster V79 cells.

Biochem/physiol Actions

Cell permeable: no

Flavonoid, antioxidant. Inhibits lipogenesis in cancer cells, most likely by targeting fatty acid synthase activity.

Primary Target
An antioxidant flavonoid that scavenges superoxide

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Other Notes

Kostyuk, V.A., et al. 1998. Arch. Biochem. Biophys. 355, 43.
Bors, W., et al. 1995. Free Radic. Biol. Med. 19, 45.
Nakayama, T., et al. 1994. Cancer Res. 54, 1991s.
Nakayama, T., et al. 1993. Biochem. Pharmacol. 45, 265.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful (C)

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c