584223
Tetrahydrouridine
≥90% (TLC), liquid, Cytidine deaminase inhibitor, Calbiochem®
別名:
InSolution Tetrahydrouridine, THU, H4U, 1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-hydroxytetrahydropyrimidin-2(1H)-one, dihydrate
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この商品について
実験式（ヒル表記法）:
C9H16N2O6 · 2H2O
CAS番号:
分子量:
284.26
NACRES:
NA.77
UNSPSC Code:
12352200
MDL number:
Assay:
≥90% (TLC)
Form:
liquid
Storage condition:
OK to freeze, avoid repeated freeze/thaw cycles, protect from light
製品名
Tetrahydrouridine, InSolution
Quality Segment
assay
≥90% (TLC)
form
liquid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, avoid repeated freeze/thaw cycles, protect from light
shipped in
dry ice
storage temp.
−70°C
SMILES string
OC1CCN([C@H]2[C@H](O)[C@H](O)[C@@H](CO)O2)C(N1)=O
InChI
1S/C9H16N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h4-8,12-15H,1-3H2,(H,10,16)/t4-,5?,6-,7-,8-/m1/s1
InChI key
UCKYOOZPSJFJIZ-XVKVHKPRSA-N
General description
A potent competitive inhibitor of cytidine deaminase. Used in combination with cytosine arabinoside (Ara-C) to assess the anti-leukemic activity and anti-tumor activity of Ara-C in in vitro studies. The solid form of this compound (Cat. No. 584222) is also available.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
cytidine deaminase
cytidine deaminase
Reversible: yes
Packaging
Packaged under inert gas
Physical form
A 100 mM (25 mg/879 µL) solution of Tetrahydrouridine (Cat. No. 584222) in H₂O.
Preparation Note
Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.
Other Notes
Yusa, K., et al. 1995. Biochem. Biophys. Res. Commun.206, 486.
Bouffard, D.Y., et al. 1993. Biochem Pharmacol.45, 1857.
Laliberte, J., et al. 1992. Cancer Chemotherap. Pharmacol.30, 7.
Riva, C., et al. 1992. Chemotherapy38, 358.
Yusa, K., et al. 1992. J. Biol. Chem.267, 16848.
Hanze, A.R. 1967. J. Am. Chem. Soc.89, 6720.
Bouffard, D.Y., et al. 1993. Biochem Pharmacol.45, 1857.
Laliberte, J., et al. 1992. Cancer Chemotherap. Pharmacol.30, 7.
Riva, C., et al. 1992. Chemotherapy38, 358.
Yusa, K., et al. 1992. J. Biol. Chem.267, 16848.
Hanze, A.R. 1967. J. Am. Chem. Soc.89, 6720.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
保管分類
12 - Non Combustible Liquids
一体何が起きているの？
WGK 3