662105
PYR-41
≥90% (sum of two isomers, HPLC), Ubiquitin E1 Inhibitor, solid
別名:
Ubiquitin E1 Inhibitor, PYR-41, 4-(4-(5-Nitro-furan-2-ylmethylene)-3,5-dioxo-pyrazolidin-1-yl)-benzoic acid ethyl ester, trihydrate, Ubiquitin-Activating Enzyme E1 Inhibitor, PYR-41
ログインで組織・契約価格をご覧ください。
サイズを選択してください
表示を変更する
この商品について
実験式（ヒル表記法）:
C17H13N3O7 · 3H2O
分子量:
425.35
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥90% (sum of two isomers, HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
製品名
Ubiquitin E1 Inhibitor, PYR-41, The Ubiquitin E1 Inhibitor, PYR-41 controls the biological activity of Ubiquitin E1. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
Quality Segment
assay
≥90% (sum of two isomers, HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
dark purple
solubility
DMSO: 10 mg/mL
shipped in
wet ice
storage temp.
−20°C
General description
A cell-permeable pyrazone compound that irreversibly (presumably via covalent modification) inhibits ubiquitin-activating enzyme E1 activity (IC50<10 µM in cell-free E1 ubiquitination reactions), while exhibiting little or no activity against E3, E2, or caspase enzymatic activity. Blocks ubiquitination-dependent protein degradation and other ubiquitination-mediated cellular activities. E1 inactivation by PYR-41 or other means has been shown to result in an overall elevation of sumoylation.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. At room temperature, compound will undergo ~1% decomposition per day.
Other Notes
Yang, Y., et al. 2007. Cancer Res.67, 9472.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Irritant (B)
保管分類
11 - Combustible Solids
一体何が起きているの？
WGK 1
引火点 (F)
Not applicable
引火点（°C）
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
662105-25MG: + 662105-VMG:
jan