676491
VEGF Inducer, GS4012
A cell-permeable pyridinyl-thioether compound that acts as a potent inducer of VEGF and VEGF-mediated vessel formation.
別名:
VEGF Inducer, GS4012, 4-(2-(4-Methoxyphenylsulfanyl)ethyl)pyridine, HCl, GS4012
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この商品について
実験式（ヒル表記法）:
C14H15NOS · xHCl
CAS番号:
分子量:
245.34 (free base basis)
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.51
Assay:
≥95% (HPLC)
Form:
solid
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light
Quality Segment
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
color
white
solubility
DMSO: 200 mg/mL, methanol: 50 mg/mL, water: soluble
shipped in
ambient
storage temp.
2-8°C
SMILES string
S(CCc2ccncc2)c1ccc(cc1)OC.Cl
InChI
1S/C14H15NOS.ClH/c1-16-13-2-4-14(5-3-13)17-11-8-12-6-9-15-10-7-12;/h2-7,9-10H,8,11H2,1H3;1H
InChI key
CYZALCLQLHDAEC-UHFFFAOYSA-N
General description
A cell-permeable and potent inducer of VEGF and VEGF-mediated blood vessel formation. GS4012-induced upregulation of VEGF correlates with its ability to suppress the gridlock/coarctation phenotype (7.5 µg/ml) in Zebrafish and to stimulate tubule network formation (5 µg/ml) in HUVECs. An essential molecule required during angioblasts cell fate determination.
A cell-permeable pyridinyl-thioether compound that acts as a potent inducer of VEGF and VEGF-mediated vessel formation. GS4012-induced upregulation of VEGF correlates well with its ability to suppress the gridlock/coarctation phenotype (7.5 µg/ml) in Zebrafish and to stimulate tubule network formation (5 µg/ml) in HUVECs.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
Potent inducer of VEGF and VEGF-mediated vessel formation
Potent inducer of VEGF and VEGF-mediated vessel formation
Product does not compete with ATP.
Reversible: no
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Peterson, R.T., et al. 2004. Nat. Biotechnol.22, 595.
Depre, C., et al. 2003. Circulation108, 2723.
Depre, C., et al. 2003. Circulation108, 2723.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
保管分類
11 - Combustible Solids
一体何が起きているの？
WGK 1
引火点 (F)
Not applicable
引火点（°C）
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
676491-1.1ML: + 676491-10MG: + 676491-MG:
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