681674
Wnt Pathway Inhibitor XI, CCT036477
The Wnt Pathway Inhibitor XI, CCT036477, also referenced under CAS 305372-78-5, controls the biological activity of Wnt Pathway. This small molecule/inhibitor is primarily used for Cancer applications.
別名:
Wnt Pathway Inhibitor XI, CCT036477, CCT036477, CRT Inhibitor VI, β-Catenin/Tcf Inhibitor VI
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この商品について
実験式（ヒル表記法）:
C21H18ClN3
CAS番号:
分子量:
347.84
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥95% (1H-NMR)
Form:
solid
Storage condition:
OK to freeze, protect from light
Quality Segment
assay
≥95% (1H-NMR)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
off-white
solubility
DMSO: 50 mg/mL
shipped in
ambient
storage temp.
2-8°C
SMILES string
Clc1ccc(cc1)C(Nc4ncccc4)c2c3c([nH]c2C)cccc3
InChI
1S/C21H18ClN3/c1-14-20(17-6-2-3-7-18(17)24-14)21(15-9-11-16(22)12-10-15)25-19-8-4-5-13-23-19/h2-13,21,24H,1H3,(H,23,25)
InChI key
IFOHRIXRQPOHQZ-UHFFFAOYSA-N
General description
A cell-permeable indole derivative that acts as an inhibitor of Wnt signaling and exhibits an inhibitory effect in a reporter cell line (IC50 = 4.6 µM) and demonstrates growth inhibition in multiple cancer cell lines, not by altering β-catenin accumulation but by blocking transcription at the β-catenin level. Displays reduced expression of Wnt target genes in myc and survivin-luciferase reporter assays, and exhibits in vivo activity by blocking the development of zebrafish at 20 µM and Xenopus embryos at 75 µM.
Packaging
Packaged under inert gas
Preparation Note
Following recontitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Ewan, K., et al. 2010. Cancer Res.70, 5963.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
保管分類
11 - Combustible Solids
wgk
WGK 2