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691400

Zebularine

Name: Zebularine
Brand: MM

≥95% (HPLC), cytidine deaminase inhibitor, solid

別名:

Zebularine, 1-(β-D-Ribofuranosyl)-1,2-dihydropyrimidin-2-one, 2-Pyrimidone-1-β-D-riboside

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この商品について

実験式（ヒル表記法）:

C₉H₁₂N₂O₅

CAS番号:

3690-10-6

分子量:

228.20

UNSPSC Code:

12352200

NACRES:

NA.32

MDL number:

MFCD04973699

Assay:

≥95% (HPLC)

Form:

solid

Storage condition:

OK to freeze

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特性

製品名

Zebularine, A cell-permeable chemically stable cytidine analog that displays antitumor properties.

Quality Segment

100

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze

color

off-white

solubility

DMSO: 5 mg/mL, methanol: 5 mg/mL

shipped in

wet ice

storage temp.

2-8°C

SMILES string

N2(C=CC=NC2=O)C1OC(C(C1O)O)CO

InChI

1S/C9H12N2O5/c12-4-5-6(13)7(14)8(16-5)11-3-1-2-10-9(11)15/h1-3,5-8,12-14H,4H2

InChI key

RPQZTTQVRYEKCR-UHFFFAOYSA-N

詳細

General description

A cell-permeable chemically stable cytidine analog that displays antitumor properties. Acts as transition state analog inhibitor of cytidine deaminase by binding at the active site as covalent hydrates. Also shown to inhibit DNA methylation and tumor growth both in vitro and in vivo.

A chemically stable, cytidine analog that displays anti-tumor properties. Acts as a transition state analog inhibitor of cytidine deaminase by binding to the active size as covalent hydrates. Also shown to inhibit DNA methylation and tumor growth both in vitro and in vivo.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
Cytidine deaminase

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

From Catalog:

Desc. Field- added "cell-permeable"

Slight warming may be required to achieve complete solubilization.

Other Notes

Cheng, J.C., et al. 2004. Cancer Cell6, 151.
Cheng, J.C., et al. 2003. J. Natl. Cancer Inst.95, 399.
Zhou, L., et al. 2002. J. Mol. Biol.321, 591.
Barchi, J.J., Jr., et al. 1992. J. Org. Chem.57, 536.
Frick, L., et al. 1989. Biochemistry28, 9423.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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保管分類

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c