8.00907
N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride
for peptide synthesis
別名:
N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride
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この商品について
実験式（ヒル表記法）:
C8H17N3 · xHCl
CAS番号:
分子量:
155.24 (free base basis)
UNSPSC Code:
12352107
EC Index Number:
247-361-2
NACRES:
NA.22
MDL number:
製品名
N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride, for synthesis
Quality Segment
form
solid
reaction suitability
reaction type: Coupling Reactions
mp
110-115 °C
application(s)
peptide synthesis
storage temp.
−20°C (−15°C to −25°C)
SMILES string
Cl.N(CCCN(CC)C#N)(C)C
InChI
1S/C8H17N3.ClH/c1-4-11(8-9)7-5-6-10(2)3;/h4-7H2,1-3H3;1H
InChI key
FDXPUDRRFDHONO-UHFFFAOYSA-N
General description
N-(3-Dimethylaminopropyl)-N-ethylcarbodiimide hydrochloride, also known as EDAC HCl or WSC, is a water-soluble condensing reagent. EDAC HCl is generally used to couple carboxylic acids with amines to form amides. The by-product urea is water-soluble and can be removed from immiscible reaction milieux by extraction with water. It is principally utilized in solution-phase peptide synthesis and as a zero-length crosslinker for protein modification.
Application
N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (EDC hydrochloride) can be used as:
- A water-soluble carbodiimide to facilitate peptide coupling reactions in alcohols.
- A coupling agent along with HOBt to synthesize poly(glutamic acid) (PGA) polypeptides for the creation of non-fouling polypeptides that could be useful in a variety of biomedical applications.
- A coupling reagent for the efficient synthesis of teriflunomide at the industrial scale.
signalword
Danger
flash_point_f
Not applicable
flash_point_c
Not applicable
target_organs
Stomach,large intestine,lymph node
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT RE 2 Oral
保管分類
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
試験成績書（COA）
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