8.51009
PyBOP®
Novabiochem®
別名:
Benzotriazole-1-yl-oxy-tris-pyrrolidino-phosphonium hexafluorophosphate, PyBOP®
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この商品について
実験式（ヒル表記法）:
C18H28N6OP · F6P
CAS番号:
分子量:
520.39
UNSPSC Code:
12352107
NACRES:
NA.22
MDL number:
Quality Segment
product line
Novabiochem®
assay
≥99.0% (HPLC)
form
powder
reaction suitability
reaction type: Coupling Reactions
manufacturer/tradename
Novabiochem®
greener alternative product characteristics
Less Hazardous Chemical Syntheses
Learn more about the Principles of Green Chemistry.
mp
140-155 °C
application(s)
peptide synthesis
greener alternative category
storage temp.
2-8°C
SMILES string
[P+](N5CCCC5)(N4CCCC4)(N3CCCC3)O[n]1nnc2c1cccc2
InChI
1S/C18H28N6OP/c1-2-10-18-17(9-1)19-20-24(18)25-26(21-11-3-4-12-21,22-13-5-6-14-22)23-15-7-8-16-23/h1-2,9-10H,3-8,11-16H2/q+1
InChI key
WGNZRLMOMHJUSP-UHFFFAOYSA-N
General description
The standard in situ coupling reagent for solid phase peptide synthesis [1,2,3,4,5]. This product can replace BOP in all applications without loss of performance. Unlike uronium-based reagents, PyBOP® does not give rise to guanidinated by-products during cyclization and fragment condensation reactions.
Associated Protocols and Technical Articles
Guide to Selection of Coupling Reagents
Literature references
[1] J. Martinez, et al. (1985) J. Med. Chem., 28, 1874.
[2] J. Coste, et al. (1990) Tetrahedron Lett., 31, 205.
[3] G. B. Fields, et al. in ′Innovation & Perspectives in Solid Phase Synthesis, 1st International Symposium′, R. Epton (Eds), SPCC UK Ltd., Birmingham, 1990, pp. 241.
[4] T. Høeg-Jensen, et al. (1991) Tetrahedron Lett., 32, 7617.
[5] R. von Eggelkraut-Gottanka, et al. (2003) Tetrahedron Lett., 44, 3551.
Associated Protocols and Technical Articles
Guide to Selection of Coupling Reagents
Literature references
[1] J. Martinez, et al. (1985) J. Med. Chem., 28, 1874.
[2] J. Coste, et al. (1990) Tetrahedron Lett., 31, 205.
[3] G. B. Fields, et al. in ′Innovation & Perspectives in Solid Phase Synthesis, 1st International Symposium′, R. Epton (Eds), SPCC UK Ltd., Birmingham, 1990, pp. 241.
[4] T. Høeg-Jensen, et al. (1991) Tetrahedron Lett., 32, 7617.
[5] R. von Eggelkraut-Gottanka, et al. (2003) Tetrahedron Lett., 44, 3551.
We are committed to bringing you greener alternative products, which adhere to one or more of the 12 Principles of Green Chemistry. PyBOP is widely used as a substitute for the BOP, with the aim of avoiding formation of hexamethylphosphoric triamide (HMPA) which is a carcinogenic side product. Click here for more information.
Analysis Note
Colour (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Assay (HPLC, area%): ≥ 99.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble
Appearance of substance (visual): powder
Identity (IR): passes test
Assay (HPLC, area%): ≥ 99.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble
Other Notes
Replaces: 01-62-0016
Legal Information
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
PyBOP is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Skin Sens. 1
保管分類
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
試験成績書（COA）
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