MILLIPLEX^® Mouse MMP Panel

The MMPs (matrix metalloproteinases), a family of zinc proteases responsible for the breakdown of extracellular matrix (ECM), play a key role in normal physiological processes, such as embryonic development and tissue morphogenesis, tissue and bone remodeling, wound healing, and angiogenesis. These processes rely on MMPs′ role in the cleavage of cell surface receptors, the release of apoptotic ligands, cell proliferation and differentiation, and chemokine activity modulation. Similar in structure, MMPs are synthesized and secreted as inactive pro-enzymes that require proteolytic cleavage for activation. This process can be mediated by serine proteases or other MMPs. An increase in MMP expression occurs in response to a wide range of stimuli, including adhesion molecules, growth factors, cytokines, and hormones. Regulation of MMP activity is controlled primarily by TIMPs (tissue inhibitors of metalloproteinases). Therefore, disruption of the MMP/TIMP balance can result in autoimmune disease, arthritis, cardiovascular disease, and tumor growth and metastasis.

MILLIPLEX^® Qualified assays undergo rigorous assay development, verification, and Quality Control testing to achieve optimal performance. Simultaneously analyze up to 2 analytes in mouse serum and plasma samples.

Analytes included: proMMP-9, MMP-12

Assay Characteristics: Refer to kit protocol for assay cross-reactivity, sensitivity, precision, and accuracy.

Dual-Analyte Detection: Simultaneous quantification of proMMP-9 and MMP-12, two critical enzymes involved in ECM remodeling and inflammation.

Multiplex Format: Uses Luminex^® xMAP^® technology, allowing for high-throughput analysis with minimal sample volume.

Verified for Serum/Plasma: Optimized for mouse serum and plasma samples with a recommended 1:2 dilution, ensuring ease of use and reliable results.

Flexible Assay Timing: Can be run overnight or in a single day, accommodating different lab workflows and schedules.

Targeted Insight into ECM Remodeling: MMP-9 and MMP-12 are key players in wound healing, angiogenesis, and immune response—ideal for studies in autoimmunity, cancer, and cardiovascular disease.

Supports Disease Modeling: Valuable for researchers investigating arthritis, tumor metastasis, and tissue regeneration, where MMP activity is a known factor.

Luminex is a registered trademark of Luminex Corp

MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany

xMAP is a registered trademark of Luminex Corp

For research use only. Not for use in diagnostic procedures.

Label License/Sticker for Assay Product:

By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.