1.50453
SeQuant® ZIC®-HILIC 200Å (5 µm) HPLC Columns
L × I.D. 100 mm x 4.6 mm HPLC Column, PEEK-lined stainless steel
別名:
Zwitterionic Hydrophilic Interaction Liquid Chromatography HPLC Column
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この商品について
UNSPSC Code:
41115709
NACRES:
NB.21
Particle size:
5 μm
Matrix active group:
ZIC-HILIC bonding phase
Pore size:
200 Å pore size
Matrix:
fully porous particle
製品名
SeQuant® ZIC-HILIC™ (5µm,200Å) PEEK 100 x 4.6 mm, suitable for HPLC
material
PEEK-lined stainless steel column
agency
suitable for USP L114
product line
SeQuant®
feature
endcapped: no
parameter
500 bar pressure, 70 °C max. temp.
technique(s)
HPLC: suitable, LC/MS: suitable, mass spectrometry (MS): suitable (High)
column L × I.D.
10 cm × 4.6 mm
matrix
fully porous particle
matrix active group
ZIC-HILIC bonding phase
particle size
5 μm
pore size
200 Å pore size
operating pH
2-7.5
separation technique
hydrophilic interaction (HILIC)
storage temp.
no temp limit
Quality Level
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General description
SeQuant® ZIC®-HILIC Columns are designed to retain and separate all types of polar and hydrophilic compounds and for robust chromatography with high selectivity and reproducibility. The silica-based ZIC®-HILIC sorbent has a bonded stationary phase consisting of a highly polar, permanent zwitterion. Separation selectivity is favored by the 1:1 zwitterion charge balance, which makes the ZIC®-HILIC Column overall neutral, with weak, but important, ionic interactions. Tuning of the selectivity on the ZIC®-HILIC Column during method development is facilitated by the pH-inpendent permanent zwitterion, ensuring that only the analytes (and not the column) are affected during eluent optimization.The Pore size of 200 Å makes this column perfectly suitable for the separation of larger polar molecules under HILIC conditions.The column dimension of 250 mm length x 2.1 mm ID is the optimal choice for the separation of complex samples using a UHPLC or optimized HPLC Instrument providing low dwell volumes.Thanks to their favorable retention and robust performance, SeQuant® HILIC columns have become extremely popular in numerous laboratories around the world. For example, US FDA (United States Food and Drug Administration) has recommended SeQuant® ZIC®-HILIC for analysis of melamine and related substances. SeQuant® HILIC columns excel in stability and low bleed. These features make them particularly suitable for LC-MS applications where high background can lead to signal suppression and interference with quantitative measurements while also increasing instrument wear. Their high stability makes these high-performance HILIC columns also attractive for traditional HPLC applications.Learn more about the Supelco HPLC Column portfolio and Method development:Brochure: HPLC and UHPLC Column Selection Guide Brochure: A Practical Guide to HPLC - Method Development Guide
Application
- Development of a HILIC method for the determination of 5-fluorouracil from nano drug delivery systems and rat skin extracts.: This study focuses on developing a HILIC method using SeQuant® ZIC-HILIC™ for the determination of 5-fluorouracil. The method was applied to analyze samples from nano drug delivery systems and rat skin extracts, highlighting its utility in pharmaceutical and biomedical research (Amasya et al., 2018).
Analysis Note
Theoretical Plates (N/m) (Cytosine): ≥ 60000
Symmetry (Cytosine): 0.95 - 1.40
Symmetry (Cytosine): 0.95 - 1.40
Legal Information
SeQuant is a registered trademark of Merck KGaA, Darmstadt, Germany
ZIC is a registered trademark of Merck KGaA, Darmstadt, Germany
ZIC-HILIC is a trademark of Merck KGaA, Darmstadt, Germany
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
プロトコル
HPLC Analysis of GMP, GDP and GTP on SeQuant ZIC-HILIC
関連コンテンツ
United States Pharmacopeia Methods - Risedronate sodium
グローバルトレードアイテム番号
| カタログ番号 | GTIN |
|---|---|
| 1.50453.0001 | 04027269134358 |
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