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Merck

ABS222

Anti-DEPTOR Antibody

from rabbit, purified by affinity chromatography

別名:

DEP domain-containing mTOR-interacting protein, DEP domain-containing protein 6

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この商品について

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702

主要文書

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製品名

Anti-DEPTOR Antibody, from rabbit, purified by affinity chromatography

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

human

technique(s)

western blot: suitable

NCBI accession no.

NP_073620

UniProt accession no.

Q8TB45

shipped in

wet ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... DEPTOR(64798)

Analysis Note

Control
HEK293 cell lyaste
Evaluated by Western Blot in HEK293 cell lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected DEPTOR in HEK293 cell lysate.

Application

Anti-DEPTOR Antibody detects level of DEPTOR & has been published & validated for use in WB.
Research Category
Metabolism
Research Sub Category
PI3K, Akt, & mTOR Signaling

Biochem/physiol Actions

Other homologies: Primate, Equine, Porcine, Canine, Rat, and Mouse based on 99%, 99%, 98%, 97%, and 96% homology, respectively.
This antibody recognizes the DEP domain that contains mTOR-interacting protein DEPTOR.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

DEPTOR (DEPDC6, DEP domain-containing protein 6) was recently identified as a novel mTOR-interacting protein whose over-expression in certain cell types represents a new mechanism for activating PI3K/Akt signaling and promoting cell survival. DEPTOR negatively regulates mTORC1 and mTORC2. It has been shown that loss of DEPTOR activates various targets that include p70S6K1, Akt, and SGK1, that leads to cell growth and survival. Little was known about DEPDC6 prior to the discovery of its interactions with mTOR, at which time it was given the new name of DEPTOR (Peterson, T.R., et al. (2009). Cell. 137(5):873-876).
~46 kDa observed.

Immunogen

Epitope: DEP domain-containing mTOR-interacting protein DEPTOR.
KLH-conjugated linear peptide corresponding to the DEP domain-containing mTOR-interacting protein of human DEPTOR.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Replaces: 09-463

Physical form

Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Preparation Note

Stable for 1 year at 2-8°C from date of receipt.

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保管分類

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

試験成績書（COA）

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Shih-Yin Tsai et al.
Cell reports, 16(7), 1903-1914 (2016-08-09)
Obesity is a major risk factor driving the global type II diabetes pandemic. However, the molecular factors linking obesity to disease remain to be elucidated. Gender differences are apparent in humans and are also observed in murine models. Here, we
Shijie Ma et al.
Oncogene, 41(17), 2431-2443 (2022-03-14)
eIF3a (eukaryotic translation initiation factor 3a), a subunit of the eIF3 complex, has been suggested to play a regulatory role in protein synthesis and in cellular response to DNA-damaging treatments. S6K1 is an effector and a mediator of mTOR complex
Amanda R Davis et al.
Frontiers in physiology, 13, 1033585-1033585 (2022-11-18)
There is strong evidence that physical activity has a profound protective effect against multiple types of cancer. Here, we show that this effect may be mediated by factors released from skeletal muscle during simulated exercise, in situ, which suppress canonical
Mélissa Carbonneau et al.
Nature communications, 7, 12700-12700 (2016-09-15)
The identification of cancer-associated mutations in the tricarboxylic acid (TCA) cycle enzymes isocitrate dehydrogenases 1 and 2 (IDH1/2) highlights the prevailing notion that aberrant metabolic function can contribute to carcinogenesis. IDH1/2 normally catalyse the oxidative decarboxylation of isocitrate into α-ketoglutarate
Jacob L Brown et al.
Journal of cachexia, sarcopenia and muscle, 9(5), 987-1002 (2018-10-18)
Cancer cachexia occurs in approximately 80% of cancer patients and is a key contributor to cancer-related death. The mechanisms controlling development of tumour-induced muscle wasting are not fully elucidated. Specifically, the progression and development of cancer cachexia are underexplored. Therefore
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関連コンテンツ

PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD
Product Selection Guide - Antibodies, small molecule inhibitors, kits, assays and proteins for signaling research.

Signaling Product Guide: Antibodies, small molecule inhibitors, kits, assays and proteins for signaling research.

グローバルトレードアイテム番号

カタログ番号GTIN
ABS22204053252632846

ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.

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