デオキシコール酸

Name: デオキシコール酸
Brand: SIGMA

≥99.0% (T)

別名:

3α,12α-ジヒドロキシ-5β-コラン酸, 7-デオキシコール酸, デスオキシコール酸

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この商品について

実験式（ヒル表記法）:

C₂₄H₄₀O₄

CAS番号:

83-44-3

分子量:

392.57

UNSPSC Code:

12352106

NACRES:

NA.77

PubChem Substance ID:

329753610

EC Number:

201-478-5

Beilstein/REAXYS Number:

3219882

MDL number:

MFCD00003673

主要文書

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InChI key

KXGVEGMKQFWNSR-LLQZFEROSA-N

InChI

1S/C24H40O4/c1-14(4-9-22(27)28)18-7-8-19-17-6-5-15-12-16(25)10-11-23(15,2)20(17)13-21(26)24(18,19)3/h14-21,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15-,16-,17+,18-,19+,20+,21+,23+,24-/m1/s1

SMILES string

C[C@H](CCC(O)=O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@]12C

biological source

ox bile

description

anionic

assay

≥99.0% (T)

form

powder

optical activity

[α]20/D +54±1°, c = 1% in ethanol

mol wt

392.57 g/mol

impurities

≤1% cholic acid (TLC)

mp

170-175 °C, 171-174 °C (lit.)

functional group

carboxylic acid

Quality Level

100

Gene Information

human ... ATIC(471)

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General description

Deoxycholic acid is an amphiphilic molecule and an important constituent of bile acid. It contains hydroxyl groups substituted at the 3α and 12α positions and a carboxyl group towards the end of the branched-chain. These moieties contribute to the hydrophilic nature of the molecule and the hydrophobic cyclopentanophenanthrene forms its center.

Application

Deoxycholic acid has been used as:

a hyphal-inhibitory compound in an ex vivo assay to study the hyphal morphogenesis of Candida albicans in the gastrointestinal tract
an internal standard to estimate the toxin concentration in the cell pellet
a bile acid (BA) standard to quantitatively measure BA in various samples from treated mice by ultra-performance liquid chromatography triple quadrupole mass spectrometry

Biochem/physiol Actions

Deoxycholic acid, due to its amphiphilicity, significantly helps to solubilize, emulsify, and absorb fat, vitamins, and cholesterol in the body. High levels of intestinal deoxycholic acid might cause colorectal cancer by inducing oxidative stress and leading to DNA damage. It acts as an oncogene and pro-tumor factor.

Other Notes

β-アドレナリン受容体の可溶化

pictograms

GHS07

signalword

Warning

hcodes

H302,H315,H319,H335

pcodes

P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

保管分類

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

30960-25G: + 30960-BULK: + 30960-100G: + 30960-VAR:

jan

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Preparation and characterizations of a novel deoxycholic acid-O-carboxymethylated chitosan-folic acid conjugates and self-aggregates

Wang F, et al.

Carbohydrate Polymers, 84, 1192-1200 (2011)

The beta-adrenergic receptor survives solubilization in deoxycholate while forming a stable association with the agonist.

E Nedivi et al.

The Journal of biological chemistry, 259(9), 5803-5808 (1984-05-10)

Agonist, but not antagonist, protects the beta-adrenergic receptor from inactivation during solubilization in deoxycholate. Protection is apparently due to locking of the agonist in the receptor, a high affinity interaction induced or stabilized by this detergent. The guanyl nucleotide-binding protein

Endogenous ursodeoxycholic acid and cholic acid in liver disease due to cystic fibrosis.

Jeffery L Smith et al.

Hepatology (Baltimore, Md.), 39(6), 1673-1682 (2004-06-09)

Focal biliary cirrhosis causes significant morbidity and mortality in cystic fibrosis (CF). Although the mechanisms of pathogenesis remain unclear, bile acids have been proposed as potential mediators of liver injury. This study examined bile acid composition in CF and assessed

Proliferative activity of rectal mucosa and soluble fecal bile acids in patients with normal colons and in patients with colonic polyps or cancer.

J Stadler et al.

Cancer letters, 38(3), 315-320 (1988-01-01)

Rectal biopsies and fecal collections were obtained from a consecutive series of 34 outpatients prior to colonoscopy at a gastroenterology clinic. Subsequently, 14 were found to have no colonic pathology, 13 had adenomatous polyps, (3 of those had a previous

The Farnesoid X receptor: a molecular link between bile acid and lipid and glucose metabolism.

Thierry Claudel et al.

Arteriosclerosis, thrombosis, and vascular biology, 25(10), 2020-2030 (2005-07-23)

Bile acids are the end products of cholesterol metabolism. They are synthesized in the liver and secreted via bile into the intestine, where they aid in the absorption of fat-soluble vitamins and dietary fat. Subsequently, bile acids return to the

デオキシコール酸

≥99.0% (T)

サイズを選択してください

この商品について

主要文書

特性

InChI key

InChI

SMILES string

biological source

description

assay

form

optical activity

mol wt

impurities

mp

functional group

Quality Level

Gene Information

関連するカテゴリー

詳細

General description

Application

Biochem/physiol Actions

Other Notes

安全性情報

pictograms

signalword

hcodes

pcodes

Hazard Classifications

target_organs

保管分類

wgk

flash_point_f

flash_point_c

ppe

適用法令

30960-25G: + 30960-BULK: + 30960-100G: + 30960-VAR:

資料

試験成績書（COA）

以前この製品を購入いただいたことがある場合

参考文献

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