30960
デオキシコール酸
≥99.0% (T)
別名:
3α,12α-ジヒドロキシ-5β-コラン酸, 7-デオキシコール酸, デスオキシコール酸
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この商品について
実験式（ヒル表記法）:
C24H40O4
CAS番号:
分子量:
392.57
UNSPSC Code:
12352106
NACRES:
NA.77
PubChem Substance ID:
EC Number:
201-478-5
Beilstein/REAXYS Number:
3219882
MDL number:
biological source
ox bile
Quality Segment
description
anionic
assay
≥99.0% (T)
form
powder
optical activity
[α]20/D +54±1°, c = 1% in ethanol
mol wt
392.57 g/mol
impurities
≤1% cholic acid (TLC)
mp
170-175 °C, 171-174 °C (lit.)
functional group
carboxylic acid
SMILES string
C[C@H](CCC(O)=O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@]12C
InChI
1S/C24H40O4/c1-14(4-9-22(27)28)18-7-8-19-17-6-5-15-12-16(25)10-11-23(15,2)20(17)13-21(26)24(18,19)3/h14-21,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15-,16-,17+,18-,19+,20+,21+,23+,24-/m1/s1
InChI key
KXGVEGMKQFWNSR-LLQZFEROSA-N
Gene Information
human ... ATIC(471)
General description
Deoxycholic acid is an amphiphilic molecule and an important constituent of bile acid. It contains hydroxyl groups substituted at the 3α and 12α positions and a carboxyl group towards the end of the branched-chain. These moieties contribute to the hydrophilic nature of the molecule and the hydrophobic cyclopentanophenanthrene forms its center.
Application
Deoxycholic acid has been used as:
- a hyphal-inhibitory compound in an ex vivo assay to study the hyphal morphogenesis of Candida albicans in the gastrointestinal tract
- an internal standard to estimate the toxin concentration in the cell pellet
- a bile acid (BA) standard to quantitatively measure BA in various samples from treated mice by ultra-performance liquid chromatography triple quadrupole mass spectrometry
Biochem/physiol Actions
Deoxycholic acid, due to its amphiphilicity, significantly helps to solubilize, emulsify, and absorb fat, vitamins, and cholesterol in the body. High levels of intestinal deoxycholic acid might cause colorectal cancer by inducing oxidative stress and leading to DNA damage. It acts as an oncogene and pro-tumor factor.
Other Notes
β-アドレナリン受容体の可溶化
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signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves