E7881
エモジン
from Frangula bark, ≥90% (HPLC), casein Kinase 2 (CK2) inhibitor
別名:
1,3,8-トリヒドロキシ-6-メチル-9,10-アントラセン ジオン, 1,3,8-トリヒドロキシ-6-メチルアントラキノン, 6-メチル-1,3,8-トリヒドロキシアントラキノン, エモドール, フラングラ-エモジン
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この商品について
実験式（ヒル表記法）:
C15H10O5
CAS番号:
分子量:
270.24
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
208-258-8
MDL number:
Beilstein/REAXYS Number:
1888141
Assay:
≥90% (HPLC)
製品名
エモジン, from Frangula bark, ≥90% (HPLC)
biological source
Frangula bark
Quality Segment
assay
≥90% (HPLC)
solubility
DMSO: soluble, aqueous base: soluble, ethanol: soluble
storage temp.
2-8°C
SMILES string
Cc1cc(O)c2C(=O)c3c(O)cc(O)cc3C(=O)c2c1
InChI
1S/C15H10O5/c1-6-2-8-12(10(17)3-6)15(20)13-9(14(8)19)4-7(16)5-11(13)18/h2-5,16-18H,1H3
InChI key
RHMXXJGYXNZAPX-UHFFFAOYSA-N
Gene Information
human ... CSNK2A1(1457), CSNK2B(1460), ELA2(1991), NFKB1(4790), NKAP(79576), NKRF(55922)
General description
Emodin is an anthraquinone derivative, extracted from rhubarb (Rheum palmatum). It has antibacterial, anti-neoplastic, anti-inflammatory and anti-angiogenesis properties. Emodin exhibits cytotoxic effects, apoptosis and stimulates the expression of hypoxia-inducible factor 1α, glutathione S-transferase P and N-acetyltransferase. It prevents the growth of prostate cancer cells. Emodin is used to treat constipation and hemorrhoid. It displays immunosuppressive and anti-diabetic effects.
Application
Emodin has been used:
- to investigate its regulatory mechanisms on lipopolysaccharide (LPS)-induced inflammatory injury in myocarditis
- as a reference standard for the development and validation of high performance liquid chromatography (HPLC)-photodiode array (PDA) assay method
- to inhibit Tau aggregation
- for direct binding assay
Biochem/physiol Actions
NF-κB活性化阻害剤、接着分子発現阻害剤。カゼインキナ-ゼII (CK2) インヒビタ-。
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signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
保管分類
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves