M6383
2-メトキシエストラジオール
≥98% (HPLC),≥98% (TLC), endothelial cell proliferation inhibitor, powder
別名:
1,3,5(10)-エストラトリエン-2,3,17-トリオール 2-メチルエーテル, 2,3,17β-トリヒドロキシ-1,3,5(10)-エストラトリエン 2-メチルエーテル, 2-ヒドロキシエストラジオール 2-メチルエーテル, 3,17β-ジヒドロキシ-2-メトキシ-1,3,5(10)-エストラトリエン
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この商品について
製品名
2-メトキシエストラジオール, powder
sterility
non-sterile
Quality Level
assay
≥98% (HPLC), ≥98% (TLC)
form
powder
color
white to faint yellow
mp
189-190 °C
solubility
DMSO: 10 mg/mL, ethanol: 10 mg/mL, H2O: insoluble
shipped in
ambient
storage temp.
room temp
SMILES string
OC1=C(C=C(C2=C1)[C@]3([H])[C@](CC2)([H])[C@]4([H])CC[C@H](O)[C@](C)4CC3)OC
InChI
1S/C19H26O3/c1-19-8-7-12-13(15(19)5-6-18(19)21)4-3-11-9-16(20)17(22-2)10-14(11)12/h9-10,12-13,15,18,20-21H,3-8H2,1-2H3/t12-,13+,15-,18-,19-/m0/s1
InChI key
CQOQDQWUFQDJMK-SSTWWWIQSA-N
Gene Information
human ... ESR1(2099), ESR2(2100)
General description
Application
- as hypoxia-inducible factor 1-alpha (HIF-1α) inhibitor to treat microglia to test whether hypoxia leads to cell death
- to determine the anticancer potential in L-lactate-activated osteosarcoma cells
- as a reference chemical and angiogenesis inhibitor to assess the performance of in vitro angiogenesis assay
Biochem/physiol Actions
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signalword
Danger
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1B - Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
target_organs
Respiratory system
保管分類
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges