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AB9742 Anti-14-3-3 σ Antibody

Anti-14-3-3 σ Antibody is an antibody against 14-3-3 σ for use in WB.

Anti-14-3-3 σ Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Neurodegenerative Diseases Gene Symbol: SFN, YWHAS, HME1, stratifin, Stratifin UniProt Number: P31947
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AB9742
100 µL  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      B, Ch, H, M, R, ShWBRbSerumPolyclonal Antibody
      Description
      Catalogue NumberAB9742
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-14-3-3 σ Antibody
      Background InformationMammals express seven distinct 14-3-3 isoforms (gamma, epsilon, beta, zeta, sigma, theta, tau) that form multiple homo- and hetero- dimmers, thus rendering 14-3-3 as a key multifunctional regulatory molecule. 14-3-3 isomers have been implicated in several neurological disorders: for example isoforms gamma, epsilon and beta are expressed in the cerebrospinal fluid of Creutzfeldt-Jakob patients, but not patients suffering from other neurological conditions such as Alzheimer's.

      The 14-3-3 sigma antibody is one of a panel of antibodies that were generated against 14-3-3 isoforms and have demonstrated their potential for use as an ELISA-based diagnostic tool. These antibodies will allow the research to investigate the role of this protein in key cellular processes and neurological disorders such as Creutzfeldt-Jakob, Alzheimer's and Parkinson's Disease.
      References
      Product Information
      FormatSerum
      PresentationLiquid.
      Quality LevelMQ100
      Applications
      ApplicationAnti-14-3-3 σ Antibody is an antibody against 14-3-3 σ for use in WB.
      Key Applications
      • Western Blotting
      Application NotesWestern blot: 1:3000

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenSynthetic peptide from the N-terminal area of sheep 14-3-3 sigma.
      HostRabbit
      Specificity14-3-3 sigma. By Western blot the antibody recognizes the ~30 kDa protein.
      Species Reactivity
      • Bovine
      • Chicken
      • Human
      • Mouse
      • Rat
      • Sheep
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • SFN
      • YWHAS
      • HME1
      • stratifin
      • Stratifin
      Purification MethodSerum
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P31947 # p53-regulated inhibitor of G2/M progression.
      SIZE: 248 amino acids; 27774 Da
      SUBUNIT: Homodimer. Interacts with KRT17 (By similarity). Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN.
      SUBCELLULAR LOCATION: Cytoplasm. Nucleus (By similarity). Secreted. Note=May be secreted by a non-classical secretory pathway.
      TISSUE SPECIFICITY: Present mainly in tissues enriched in stratified squamous keratinising epithelium.
      SIMILARITY: SwissProt: P31947 ## Belongs to the 14-3-3 family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      AB9742 04053252674365

      Documentation

      Anti-14-3-3 σ Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-14-3-3 σ Antibody Certificates of Analysis

      TitleLot Number
      RABBIT ANTI-14-3-3 sigma - 2038235 2038235
      RABBIT ANTI-14-3-3 sigma - 3277979 3277979

      References

      Reference overviewPub Med ID
      Identification of 14-3-3 proteins in human platelets: effects of synthetic peptides on protein kinase C activation
      Wheeler-Jones, C P, et al
      Biochem J, 315 ( Pt 1):41-7 (1996)  1996

      		8670130 8670130

      Data Sheet

      Title
      Anti-14-3-3 sigma - Data Sheet

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies