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AB3152 Anti-Amphiregulin Antibody

This Anti-Amphiregulin Antibody is validated for use in ELISA, IP, WB for the detection of Amphiregulin.

Anti-Amphiregulin Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Neurochemistry & Neurotrophins Gene Symbol: AREG, MGC13647, CRDGF, amphiregulin, AR, SDGF UniProt Number: P15514
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AB3152
100 µg  
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      Overview

      Replacement Information

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MELISA, IP, WBRbPurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB3152
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Amphiregulin Antibody
      Alternate Names
      • AR
      • CRDGF
      • KAF
      References
      Product Information
      FormatPurified
      PresentationPurified immunoglobulin from rabbit anti-serum by Protein A chromatography. Liquid in 10mM PBS, pH 7.4, with 0.2% BSA and 15mM sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-Amphiregulin Antibody is validated for use in ELISA, IP, WB for the detection of Amphiregulin.
      Key Applications
      • ELISA
      • Immunoprecipitation
      • Western Blotting
      Application NotesImmunoprecipitation (Use Protein A): Ab 10μg/mg protein lysate.

      Western Blotting: Ab 5μg/ml for 2hrs at room temperature.

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenA synthetic 19-mer peptide, corresponding to aa 26-44 from the secreted amphiregulin of human origin.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityRecognizes a glycoprotein of 18.5-22.5kDa, identified as amphiregulin (AR). Antibody is directed against the region of AR, which binds to heparin and is highly specific to AR. It shows no cross-reaction with EGF, TGFalpha, or HB-EGF. In vitro, AR functions as an autocrine growth stimulator to derive proliferation of colon carcinoma cells, normal and oncogene-transformed mammary epithelial cells, cervical carcinoma cells, prostate cancer cells, and keratinocytes. AR is important in development of human placenta and murine mammary gland.
      Species Reactivity
      • Human
      • Mouse
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells, and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). This protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells and inhibits the growth of certain aggressive carcinoma cell lines. This encoded protein is associated with a psoriasis-like skin phenotype.
      Gene Symbol
      • AREG
      • MGC13647
      • CRDGF
      • amphiregulin
      • AR
      • SDGF
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P15514 # Bifunctional growth-modulating glycoprotein. Inhibits growth of several human carcinoma cells in culture and stimulates proliferation of human fibroblasts and certain other tumor cells.
      SIZE: 252 amino acids; 27895 Da
      SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein.
      SIMILARITY: SwissProt: P15514 ## Belongs to the amphiregulin family. & Contains 1 EGF-like domain.
      MISCELLANEOUS: AR is a protein containing cysteines in disulfide linkage(s) that are essential for its biological activity. AR may contain oligosaccharides and/or lipid moieties that are not obligatory for the biological activity.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      AB3152 04053252731754

      Documentation

      Anti-Amphiregulin Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Amphiregulin Antibody Certificates of Analysis

      TitleLot Number
      RABBIT ANTI-AMPHIREGULIN 2830926
      RABBIT ANTI-AMPHIREGULIN - 3321167 3321167
      RABBIT ANTI-AMPHIREGULIN - 3835393 3835393
      RABBIT ANTI-AMPHIREGULIN - 4116921 4116921
      RABBIT ANTI-AMPHIREGULIN -2851253 2851253
      RABBIT ANTI-AMPHIREGULIN POLYCLONAL ANTIBODY 3036930
      RABBIT ANTI-AMPHIREGULIN POLYCLONAL ANTIBODY 3079146
      RABBIT ANTI-AMPHIREGULIN POLYCLONAL ANTIBODY 2935538
      RABBIT ANTI-AMPHIREGULIN POLYCLONAL ANTIBODY - 2080269 2080269
      RABBIT ANTI-AMPHIREGULIN POLYCLONAL ANTIBODY -2582839 2582839
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      References

      Reference overviewPub Med ID
      Structure and function of human amphiregulin: a member of the epidermal growth factor family
      Shoyab, M, et al
      Science, 243:1074-1076 (1989)  1989

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