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ABT240 Anti-Ankyrin-B

This rabbit polyclonal Anti-Ankyrin-B, Cat. No. ABT240, is a rabbit polyclonal antibody that detects Ankyrin-B and has been tested for use in Immunohistochemistry (Paraffin) and Western Blotting,

Anti-Ankyrin-B MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Cell Structure Gene Symbol: ANK2 UniProt Number: Q01484
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ABT240
100 μg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HIH(P), WBRbPurifiedPolyclonal Antibody
      Description
      Catalogue NumberABT240
      DescriptionAnti-Ankyrin-B
      Alternate Names
      • ANK-2
      • ANK-2
      • Ankyrin-B
      • Brain Ankyrin
      • Non-erythroid Ankyrin
      Background InformationAnkyrin-2 (UniProt: Q01484; also known as ANK-2, Ankyrin-B, Brain Ankyrin, Non-erythroid Ankyrin) is encoded by the ANK2 gene (Gene ID: 287) in human. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain, which is the least conserved and subject to variation. ANK-2 is a cytoskeletal protein that is present in plasma membrane of neurons as well as glial cells throughout the brain and it is expressed in fetal brain and in temporal cortex of adult brain. Its expression is also shown in the inner segments of rod photoreceptors in retina and at the apical membrane of airway lung epithelial cells. Four isoforms of ANK-2 have been reported that are produced by alternative splicing. ANK-2 can be phosphorylated at multiple sites by different protein kinases and each phosphorylation event regulates its structure and function. In skeletal muscle, ANK-2 is required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. Mutations in ANK2 gene are known to cause Long QT syndrome 4 (LQT4), which is characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. It can cause syncope (temporary loss of consciousness caused by a fall in blood pressure) and sudden death in response to exercise or emotional stress.
      References
      Product Information
      FormatPurified
      PresentationPurified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine, 0.15 M NaCl, pH7.4 with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis rabbit polyclonal Anti-Ankyrin-B, Cat. No. ABT240, is a rabbit polyclonal antibody that detects Ankyrin-B and has been tested for use in Immunohistochemistry (Paraffin) and Western Blotting,
      Key Applications
      • Immunohistochemistry (Paraffin)
      • Western Blotting
      Application NotesImmunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected Ankyrin-B in mouse striatum and mouse hippocampus tissues.

      Western Blotting Analysis: 1 µg/mL from a representative lot detected Ankyrin-B in SK-N-SH cell lysate.
      Biological Information
      ImmunogenGST-tagged Recombinant Protein corresponding to the cytoplasmic domain of Human Ankyrin-B.
      Epitopecytoplasmic domain
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      SpecificityThis rabbit polyclonal antibody detects Ankyrin-B in human cells. It targets an epitope within 228 amino acids from the internal region.
      Species Reactivity
      • Human
      Species Reactivity NoteHuman.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • ANK2
      Purification MethodAffinity Purified
      UniProt Number
      Molecular Weight433.72 kDa calculated.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunohistochemistry in human cerebral cortex tissue.

      Immunohistochemistry Analysis: A 1:1,000 dilution of this antibody detected Ankyrin-B in human cerebral cortex tissue.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABT240 04054839412356