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ABC508 Anti-BTG3 Antibody

This Anti-BTG3 Antibody is validated for use in Western Blotting and Immunohistochemistry (Paraffin) for the detection of BTG3.

Anti-BTG3 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: BTG3, ANA, TOB5 UniProt Number: Q14201
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ABC508
100 µL  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IH(P)RbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABC508
      DescriptionAnti-BTG3 Antibody
      Alternate Names
      • Protein BTG3
      • Abundant in neuroepithelium area protein
      • BTG family member 3
      • Protein Tob5
      Background InformationBTG3 is a tumor suppression protein because overexpression impairs serum-induced cell cycle progression from G0/G1 to the S phase in vitro. BTG3 is often down regulated in cancer cell lines, and thus BTG3 is a target for enhanced cancer therapy. In normal cells BTG3 inhibits cell proliferation, cell invasion, and angiogenesis, and also regulates cell-cycle progression and differentiation in a variety of cell types. Developmentally BTG3 is normally expressed primarily in the brain and CNS during development where is modulates cell proliferation. In the adult expression is high in ovary, testis, prostate, thymus and lung. It is not expressed strongly in many cancers.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-BTG3 Antibody is validated for use in Western Blotting and Immunohistochemistry (Paraffin) for the detection of BTG3.
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a representative lot detected BTG3 in human testis and human prostate tissue.
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to human BTG3.
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      Species Reactivity
      • Human
      Species Reactivity NoteHuman. This antibodies immunogen is 94% identical in mouse and 92% identical in rat.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • BTG3
      • ANA
      • TOB5
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~37 kDa observed. Uncharacterized bands may be observed in some lysates. The calculated molecular weight of this protein is 29 kDa, but can be observed at ~37 kDa due to alternate splice variants.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in IMR-90 cell lysate.

      Western Blotting Analysis: A 1:500 dilution of this antibody detected BTG3 in 10 µg of IMR-90 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABC508 04055977109214