Millipore Sigma Vibrant Logo

AB5370P Anti-Capsaicin Receptor Antibody, CT

Anti-Capsaicin Receptor Antibody, C-terminus is an antibody against Capsaicin Receptor for use in IH.

Anti-Capsaicin Receptor Antibody, CT MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Neuroinflammation & Pain, Neurotransmitters & Receptors Gene Symbol: TRPV1, VR1, OTRPC1, DKFZp434K0220, TrpV1 UniProt Number: Q8NER1
View Products on Sigmaaldrich.com
AB5370P
20 µg  
Retrieving price...
Price could not be retrieved
Minimum Quantity is a multiple of
Maximum Quantity is
Upon Order Completion More Information
You Saved ()
 
—
Request Pricing
—
Limited Availability Limited Availability
In Stock 
Discontinued
Limited Quantities Available
Availability to be confirmed
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

      Special Offers

       

      Contact Customer Service

      Overview

      Replacement Information

      Special Offers

      100% Performance Guaranteed

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, RIHCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB5370P
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Capsaicin Receptor Antibody, CT
      Alternate Names
      • Vanilloid Receptor 1
      • VR1
      References
      Product Information
      FormatAffinity Purified
      PresentationAffinity purified immunoglobulin. Lyophilized. Contains no preservative. Reconstitute with 20 μL of sterile distilled water. Centrifuge if necessary to remove any residue.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Capsaicin Receptor Antibody, C-terminus is an antibody against Capsaicin Receptor for use in IH.
      Key Applications
      • Immunohistochemistry
      Application NotesImmunohistochemistry: 1-2 μg/mL.

      The antibody reacts well with tissue from the rat dorsal root ganglia.

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenA 21 amino acid peptide corresponding to the C-terminus of the rat Capsaicin Receptor protein.
      EpitopeC-terminus
      HostRabbit
      SpecificityCapsaicin Receptor (Vanilloid Receptor 1, VR1).
      Species Reactivity
      • Human
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryCapsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Four transcript variants encoding the same protein, but with different 5' UTR sequence, have been described for this gene.
      Gene Symbol
      • TRPV1
      • VR1
      • OTRPC1
      • DKFZp434K0220
      • TrpV1
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q8NER1 # Receptor-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. May be involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL.
      SIZE: 839 amino acids; 94938 Da
      SUBUNIT: Self-associates. Probably homotetramer. May also form a heteromeric channel with TRPV3. Interacts with calmodulin, PRKCM and CSK. Interacts with PRKCG and NTRK1, probably by forming a trimeric complex (By similarity).
      SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity).
      TISSUE SPECIFICITY: Widely expressed at low levels. Expression is elevated in dorsal root ganglia. In skin, expressed in cutaneous sensory nerve fibers, mast cells, epidermal keratinocytes, dermal blood vessels, the inner root sheet and the infundibulum of hair follicles, differentiated sebocytes, sweat gland ducts, and the secretory portion of eccrine sweat glands (at protein level).DOMAIN:SwissProt: Q8NER1 The association domain (AD) is necessary for self- association (By similarity).
      PTM: Phosphorylation by PKA reverses capsaicin-induced dephosphorylation at multiple sites, probably including Ser-117 as a major phosphorylation site. Phoshphorylation by CAMKII seems to regulate binding to vanilloids. Phosphorylated and modulated by PKCM and probably PKCZ. Dephosphorylation by calcineurin seems to lead to receptor desensitization and phosphorylation by CAMKII recovers activity (By similarity).
      SIMILARITY: Belongs to the transient receptor family. TrpV subfamily. & Contains 3 ANK repeats.
      MISCELLANEOUS: Responses evoked by low pH and heat, and capsaicin can be antagonized by capsazepine.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain lyophilized material at -20°C to -70°C for up to 6 months. After reconstitution maintain frozen at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. Glycerol (1:1) can be added for additional stability.
      Packaging Information
      Material Size20 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      AB5370P 04053252279058

      Documentation

      Anti-Capsaicin Receptor Antibody, CT SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Capsaicin Receptor Antibody, CT Certificates of Analysis

      TitleLot Number
      RABBIT ANTI-CAPSAICIN RECEPTOR (VANILLOID RECEPTOR 1, VR1, TRPV1) - 3421950 3421950
      RABBIT ANTI-CAPSAICIN RECEPTOR (VANILLOID RECEPTOR 1, VR1, TRPV1) AFFINITY PURIFIED, POLYCLONAL ANTIBODY 2937876
      RABBIT ANTI-CAPSAICIN RECEPTOR (VANILLOID RECEPTOR 1, VR1, TRPV1) AFFINITY PURIFIED, POLYCLONAL ANTIBODY 2967783
      RABBIT ANTI-CAPSAICIN RECEPTOR (VANILLOID RECEPTOR 1, VR1, TRPV1) AFFINITY PURIFIED, POLYCLONAL ANTIBODY 2935539
      RABBIT ANTI-CAPSAICIN RECEPTOR (VANILLOID RECEPTOR 1, VR1, TRPV1) AFFINITY PURIFIED, POLYCLONAL ANTIBODY - 2048753 2048753
      RABBIT ANTI-CAPSAICIN RECEPTOR (VANILLOID RECEPTOR 1, VR1, TRPV1) AFFINITY PURIFIED, POLYCLONAL ANTIBODY - 2110457 2110457
      RABBIT ANTI-CAPSAICIN RECEPTOR (VANILLOID RECEPTOR 1, VR1, TRPV1) AFFINITY PURIFIED, POLYCLONAL ANTIBODY - 2281630 2281630
      RABBIT ANTI-CAPSAICIN RECEPTOR -2639446 2639446

      References

      Reference overviewApplicationSpeciesPub Med ID
      Expression and distribution of vannilloid receptor 1 (TRPV1) in the adult rat brain
      Toth, A. et al.
      Molecular Brain Research, 135:162-168 (2005)  2005

      		Immunoblotting (Western), Immunohistochemistry (Tissue)Rat15857679 15857679

      Related Products & Applications

      Related Products

      Catalogue Number Description  
      AB5370 Anti-Capsaicin Receptor Antibody, CT Show Pricing & Availability
      AB5566 Anti-Capsaicin Receptor Antibody, CT Show Pricing & Availability
      AB5889 Anti-Capsaicin Receptor Antibody, NT Show Pricing & Availability

      Alternative Format

      Catalogue Number Description  
      AB5370 Anti-Capsaicin Receptor Antibody, CT Show Pricing & Availability

      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies