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MABC1704-25UG Anti-Eotaxin Antibody, clone 13H2

Anti-Eotaxin, clone 13H2, Cat. No. MABC1704, is a mouse monoclonal antibody that detects Eotaxin and has been tested for use in Immunohistochemistry (Paraffin) and Western Blotting.

MABC1704-25UG
25 μg  
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      Overview

      Replacement Information
      Description
      Catalogue NumberMABC1704-25UG
      DescriptionAnti-Eotaxin Antibody, clone 13H2
      Alternate Names
      • C-C motif chemokine 11
      • Eosinophil chemotactic protein
      • Small-inducible cytokine A11
      Background InformationEotaxin (UniProt: P51671; also known as C-C motif chemokine 11, Eosinophil chemotactic protein, Small-inducible cytokine A11) is encoded by the CCL11 (also known as SCYA11) gene (Gene ID: 6356) in human. Eotaxin is a potent and eosinophil-specific chemoattractant that plays a critical role in allergic and nonallergic inflammatory reactions. In response to the presence of allergens it directly promotes the accumulation of eosinophils at the site of inflammation. It is constitutively expressed in several tissues including intestine, lymphoid node, thymus, skin, heart, kidney, and mammary gland. It is a secreted protein that is synthesized with a signal peptide (aa 1-23), which is subsequently cleaved off to produce the mature form. Eotaxin is shown to be induced by TNFa, IL-1a, and IFN-g. In addition to its role in immune response, Eotaxin is also associated with aging, neurogenesis and neurodegeneration and can influence neural progenitor cells, and microglia. Its elevated circulating levels have been shown in several psychiatric disorders, including schizophrenia, bipolar disorder, and major depression. (Ref.: Teixeira, AL., et al. (2018). Front Psychiatry. 9; 241; Salcedo, R., et al. (2001). J. Immunol. 166(12); 7571-7578).
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal antibody IgG1 in PBS with 0.05% sodium azide.
      Quality LevelMQ200
      Applications
      ApplicationAnti-Eotaxin, clone 13H2, Cat. No. MABC1704, is a mouse monoclonal antibody that detects Eotaxin and has been tested for use in Immunohistochemistry (Paraffin) and Western Blotting.
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemistry (Paraffin) Analysis: A 1:50 dilution from a representative lot detected Eotaxin in human skin and human small intestine tissue sections.

      Note: Actual optimal working dilutions must be determined by end user as specimens, and experimental conditions may vary with the end user
      Biological Information
      ImmunogenFull-length recombinant mature human Eotaxin
      EpitopeUnknown
      Clone13H2
      Concentration1 mg/mL. Please refer to guidance on suggested starting dilutions and/or titers per application and sample type.
      HostMouse
      SpecificityClone 13H2 is a mouse monoclonal antibody that detects human Eotaxin.
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Species Reactivity NoteHuman.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • CCL11
      • SCYA11
      Purification MethodProtein G purified
      UniProt Number
      Molecular Weight~12 kDa observed; 10.73 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting with human recombinant Eotaxin.

      Western Blotting Analysis: 1:50,000 dilution of this antibody detected recombinant human Eotaxin.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at +2°C to +8°C from date of receipt.
      Packaging Information
      Material Size25 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABC1704-25UG 04061841879862