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GR38 Anti-IGF-IR (Ab-4) Mouse mAb (24-31)

Anti-IGF-IR (Ab-4) Mouse mAb (24-31) MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Anti-IGF-R, Anti-Insulin-Like Growth Factor Receptor

GR38
  
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      Overview

      Replacement Information

      Key Spec Table

      Host
      M
      Description
      Overview

      This product has been discontinued.





      Recognizes the ~130 kDa α-subunit of the IGF-I receptor protein in placenta tissue.
      Catalogue NumberGR38
      Brand Family Calbiochem®
      SynonymsAnti-IGF-R, Anti-Insulin-Like Growth Factor Receptor
      References
      ReferencesDore, S., et al. 1997. Trends Neurosci. 20, 326.
      Dore, S., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 4772.
      Walter, H.J., et al. 1997. Endocrinology 138. 3024.
      Beilharz, E.J., et al. 1995. Mol. Brain Res. 29, 81.
      Jones, J.I. and Clemmons, D.R. 1995. Endocr. Rev. 16, 3.
      Takahashi, et al. 1995. Br. J. Cancer 72, 813.
      Schumacher, R., et al. 1993. J. Biol. Chem. 268, 1087.
      Soos, M.A., et al. 1993. Adv. Exper. Med. Biol. 343, 145.
      Soos, M.A., et al. 1992. J. Biol. Chem. 267, 12955.
      Product Information
      FormLiquid
      FormulationIn 10 mM PBS, 0.2% BSA, pH 7.4.
      Positive controlPlacenta tissue
      Preservative≤0.1% sodium azide
      Applications
      Application ReferencesOriginal Clone Takahashi, et al. 1995. Br. J. Cancer 72, 813. Species Reactivity Takahashi, et al. 1995. Br. J. Cancer 72, 813. Soos, M.A., et al. 1993. Adv. Exper. Med. Biol. 343, 145. Soos, M.A., et al. 1992. J. Biol. Chem. 267, 12955.
      Key Applications Enzyme-Linked Immunosorbent Assay
      Immunoprecipitation
      Not Western Blot
      Application NotesELISA (see comments)
      Immunoblotting (not recommended)
      Immunoprecipitation (10 µl/mg protein lysate)
      Application CommentsNo cross-reactivity with insulin receptor. This antibody does not significantly inhibit IGF-1 binding. This antibody has also been reported to work for ELISA. Antibody should be titrated for optimal results in individual systems.
      Biological Information
      ImmunogenIGF-IR/3T3 fibroblasts transfected with human IGF-I receptor
      ImmunogenHuman
      Epitopewithin amino acids 283-440 of IGF-1R
      Clone24-31
      HostMouse
      IsotypeIgG₁
      Concentration Label Please refer to vial label for lot-specific concentration
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFor long-term storage, aliquot and freeze (-20°C). Avoid freeze/thaw cycles.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      GR38 0

      Documentation

      Anti-IGF-IR (Ab-4) Mouse mAb (24-31) SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-IGF-IR (Ab-4) Mouse mAb (24-31) Certificates of Analysis

      TitleLot Number
      GR38

      References

      Reference overview
      Dore, S., et al. 1997. Trends Neurosci. 20, 326.
      Dore, S., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 4772.
      Walter, H.J., et al. 1997. Endocrinology 138. 3024.
      Beilharz, E.J., et al. 1995. Mol. Brain Res. 29, 81.
      Jones, J.I. and Clemmons, D.R. 1995. Endocr. Rev. 16, 3.
      Takahashi, et al. 1995. Br. J. Cancer 72, 813.
      Schumacher, R., et al. 1993. J. Biol. Chem. 268, 1087.
      Soos, M.A., et al. 1993. Adv. Exper. Med. Biol. 343, 145.
      Soos, M.A., et al. 1992. J. Biol. Chem. 267, 12955.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision27-August-2007 RFH
      SynonymsAnti-IGF-R, Anti-Insulin-Like Growth Factor Receptor
      ApplicationELISA (see comments)
      Immunoblotting (not recommended)
      Immunoprecipitation (10 µl/mg protein lysate)
      DescriptionPurified mouse monoclonal antibody generated by immunizing BALB/c mice with the specified immunogen and fusing splenocytes with NSO/1 mouse myeloma cells (see application references). Recognizes the ~130 kDa α-subunit of the IGF-I receptor protein.
      BackgroundThe insulin growth factor (IGF) family, which includes IGF-I and IGF-II, binds to the IGF receptors (IGFRs) to mediate a number of biological effects. At least six IGF binding proteins (IGFBP-1-6) have also been identified which complex with the IGFs to modulate interactions with the receptors in either a stimulatory or inhibitory manner. Expression of these proteins is regulated during development, and is both tissue and cell specific. IGF-I exhibits potent effects on motor neuron survival, modulates neurotransmitter activity, and reduces apoptosis during normal development and axotomy. In addition, IGF-I serves a neuroprotective role against β-amyloid induced toxicity. It has also been demonstrated that IGF-I, IGF-II, and several IGFBPs are spatiotemporally regulated following hypoxic-ischemic brain injuries.
      HostMouse
      Immunogen speciesHuman
      ImmunogenIGF-IR/3T3 fibroblasts transfected with human IGF-I receptor
      Epitopewithin amino acids 283-440 of IGF-1R
      Clone24-31
      IsotypeIgG₁
      Specieshuman, rabbit (weakly), not rat
      Positive controlPlacenta tissue
      FormLiquid
      FormulationIn 10 mM PBS, 0.2% BSA, pH 7.4.
      Concentration Label Please refer to vial label for lot-specific concentration
      Preservative≤0.1% sodium azide
      CommentsNo cross-reactivity with insulin receptor. This antibody does not significantly inhibit IGF-1 binding. This antibody has also been reported to work for ELISA. Antibody should be titrated for optimal results in individual systems.
      Storage Avoid freeze/thaw
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFor long-term storage, aliquot and freeze (-20°C). Avoid freeze/thaw cycles.
      Toxicity Standard Handling
      ReferencesDore, S., et al. 1997. Trends Neurosci. 20, 326.
      Dore, S., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 4772.
      Walter, H.J., et al. 1997. Endocrinology 138. 3024.
      Beilharz, E.J., et al. 1995. Mol. Brain Res. 29, 81.
      Jones, J.I. and Clemmons, D.R. 1995. Endocr. Rev. 16, 3.
      Takahashi, et al. 1995. Br. J. Cancer 72, 813.
      Schumacher, R., et al. 1993. J. Biol. Chem. 268, 1087.
      Soos, M.A., et al. 1993. Adv. Exper. Med. Biol. 343, 145.
      Soos, M.A., et al. 1992. J. Biol. Chem. 267, 12955.
      Application referencesOriginal Clone Takahashi, et al. 1995. Br. J. Cancer 72, 813. Species Reactivity Takahashi, et al. 1995. Br. J. Cancer 72, 813. Soos, M.A., et al. 1993. Adv. Exper. Med. Biol. 343, 145. Soos, M.A., et al. 1992. J. Biol. Chem. 267, 12955.