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PC542 Anti-MMP-13 (Ab-8) Rabbit pAb

Anti-MMP-13 (Ab-8) Rabbit pAb MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Anti-Collagenase-3, Anti-Matrix Metalloproteinase 13

PC542
  
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      Overview

      Replacement Information

      Key Spec Table

      Host
      Rb
      Description
      Overview

      This product has been discontinued.





      Recognizes MMP-13 in breast carcinoma tissue.
      Catalogue NumberPC542
      Brand Family Calbiochem®
      SynonymsAnti-Collagenase-3, Anti-Matrix Metalloproteinase 13
      Application Data
      Detection of human MMP-13 by staining paraffin sections. Sample: Human breast carcinoma tissue. Primary antibody: Anti-MMP-13 (Ab-8) Rabbit pAb (Cat. No. PC542) (2.5 µg/ml). Detection: DAB, methyl green counterstain.
      References
      ReferencesBostrom, P.J., et al. 2000. Int. J. Cancer 88, 417.
      Hofmann, U.B., et al. 2000. J. Invest. Dermatol. 115, 337.
      Mengshol, J.A., et al. 2000. Arthritis Rheum. 43, 801.
      Pendas, A.M., et al. 2000. Clin. Chim. Acta 291, 137.
      Selvamurugan, N. and Partridge, N.C. 2000. Mol. Cell. Biol. Res. Commun. 3, 218.
      Tuckermann, J.P., et al. 2000. J. Bone Miner. Res. 15, 1257.
      Winchester, S.K., et al. 2000. J. Biol. Chem. 275, 23310.
      Ye, H.Q., et al. 2000. Invest. Ophthalmol. Vis. Sci. 41, 2894.
      Barmina, O.Y., et al. 1999. J. Biol. Chem. 274, 30087.
      Botos, I., et al. 1999. J. Mol. Biol. 292, 837.
      Winchester, S.K., et al. 1999. J. Cell Physiol. 181, 479.
      Johansson, N., et al. 1997. Am. J. Pathol. 151, 499.
      Product Information
      FormLiquid
      FormulationIn 0.05 M sodium phosphate buffer, 50% glycerol.
      Positive controlRecombinant MMP-13 or breast carcinoma tissue
      PreservativeNone
      Applications
      Key Applications Immunoblotting (Western Blotting)
      Paraffin Sections
      Application NotesImmunoblotting (2.5 µg/ml)
      Paraffin Sections (2.5 µg/ml, no pre-treatment required)
      Application CommentsAntibody should be titrated for optimal results in individual systems.
      Biological Information
      Immunogenrecombinant, human MMP-13
      ImmunogenHuman
      HostRabbit
      IsotypeIgG
      Concentration Label Please refer to vial label for lot-specific concentration
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      PC542 0

      Documentation

      References

      Reference overview
      Bostrom, P.J., et al. 2000. Int. J. Cancer 88, 417.
      Hofmann, U.B., et al. 2000. J. Invest. Dermatol. 115, 337.
      Mengshol, J.A., et al. 2000. Arthritis Rheum. 43, 801.
      Pendas, A.M., et al. 2000. Clin. Chim. Acta 291, 137.
      Selvamurugan, N. and Partridge, N.C. 2000. Mol. Cell. Biol. Res. Commun. 3, 218.
      Tuckermann, J.P., et al. 2000. J. Bone Miner. Res. 15, 1257.
      Winchester, S.K., et al. 2000. J. Biol. Chem. 275, 23310.
      Ye, H.Q., et al. 2000. Invest. Ophthalmol. Vis. Sci. 41, 2894.
      Barmina, O.Y., et al. 1999. J. Biol. Chem. 274, 30087.
      Botos, I., et al. 1999. J. Mol. Biol. 292, 837.
      Winchester, S.K., et al. 1999. J. Cell Physiol. 181, 479.
      Johansson, N., et al. 1997. Am. J. Pathol. 151, 499.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision11-October-2007 RFH
      SynonymsAnti-Collagenase-3, Anti-Matrix Metalloproteinase 13
      ApplicationImmunoblotting (2.5 µg/ml)
      Paraffin Sections (2.5 µg/ml, no pre-treatment required)
      Application Data
      Detection of human MMP-13 by staining paraffin sections. Sample: Human breast carcinoma tissue. Primary antibody: Anti-MMP-13 (Ab-8) Rabbit pAb (Cat. No. PC542) (2.5 µg/ml). Detection: DAB, methyl green counterstain.
      DescriptionPurified rabbit polyclonal antibody. Recognizes MMP-13.
      BackgroundMMP-13 (~54 kDa), also known as collagenase-3, was originally identified in breast carcinomas but has since been shown to be present in high concentrations in other cancers, particularly in highly metastatic squamous-cell carcinomas of the head, neck, and vulva, in cutaneous basal-cell carcinomas, chondrosarcomas, melanomas, and in urinary bladder carcinomas. Expression of MMP-13 is not restricted to tumors and has been shown to also have a role in the repair of corneal wounding, and in the normal differentiation of osteoblasts. Mechanistically, MMP-13 appears to bind to a specific cell surface receptor and following interaction with the low-density lipoprotein receptor-related protein is internalized by the target cell. Like other members of the MMP family, MMP-13 has multiple substrate specificities including type II collagen, cartilage, fibronectin, and aggrecan.
      HostRabbit
      Immunogen speciesHuman
      Immunogenrecombinant, human MMP-13
      IsotypeIgG
      Specieshuman, not mouse
      Positive controlRecombinant MMP-13 or breast carcinoma tissue
      FormLiquid
      FormulationIn 0.05 M sodium phosphate buffer, 50% glycerol.
      Concentration Label Please refer to vial label for lot-specific concentration
      PreservativeNone
      CommentsAntibody should be titrated for optimal results in individual systems.
      Storage Avoid freeze/thaw
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Toxicity Standard Handling
      ReferencesBostrom, P.J., et al. 2000. Int. J. Cancer 88, 417.
      Hofmann, U.B., et al. 2000. J. Invest. Dermatol. 115, 337.
      Mengshol, J.A., et al. 2000. Arthritis Rheum. 43, 801.
      Pendas, A.M., et al. 2000. Clin. Chim. Acta 291, 137.
      Selvamurugan, N. and Partridge, N.C. 2000. Mol. Cell. Biol. Res. Commun. 3, 218.
      Tuckermann, J.P., et al. 2000. J. Bone Miner. Res. 15, 1257.
      Winchester, S.K., et al. 2000. J. Biol. Chem. 275, 23310.
      Ye, H.Q., et al. 2000. Invest. Ophthalmol. Vis. Sci. 41, 2894.
      Barmina, O.Y., et al. 1999. J. Biol. Chem. 274, 30087.
      Botos, I., et al. 1999. J. Mol. Biol. 292, 837.
      Winchester, S.K., et al. 1999. J. Cell Physiol. 181, 479.
      Johansson, N., et al. 1997. Am. J. Pathol. 151, 499.