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04-145 Anti-NOD2 Antibody, clone 2D9

Anti-NOD2 Antibody, clone 2D9 is a Mouse Monoclonal Antibody for detection of NOD2 also known as NOD-like receptor C2 & has been validated in IHC, WB & IP.

Anti-NOD2 Antibody, clone 2D9 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Inflammation & Immunology Research Sub-Category: Immunological Signaling Gene Symbol: NOD2, ACUG, BLAU, CARD15, CD, CLR16.3, IBD1, NLRC2, NOD2B, PSORAS1 UniProt Number: Q9HC29
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04-145
100 µg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HIHC, WB, IPMPurifiedMonoclonal Antibody
      Description
      Catalogue Number04-145
      DescriptionAnti-NOD2 Antibody, clone 2D9
      Alternate Names
      • Caspase recruitment domain-containing protein 15
      • Inflammatory bowel disease protein 1
      • NLR family, CARD domain containing 2
      • NOD-like receptor C2
      • caspase recruitment domain family, member 15
      • caspase recruitment domain protein 15
      • nucleotide-binding oligomerization domain 2
      • nucleotide-binding oligomerization domain containing 2
      • nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 2
      Background InformationNOD2 (nucleotide-binding oligomerization domain containing 2), also known as the caspase recruitment domain family, member 15 (CARD15), is a member of the NOD-like Receptor (NLR) family of proteins and plays an important role in the immune system. It is an intracellular pattern recognition receptor and is linked to inflammatory diseases such as inflammatory bowel disease/Crohn's Disease and Blau syndrome. NOD2 has two caspase recruitment domains (CARDs) and eleven leucine-rich repeats (LRRs). The protein is primarily expressed in the peripheral blood leukocytes. It plays a role in the immune response by recognizing the bacterial molecules. Recently it is has been found to interact with NLRC4 and bind to MAVS in response to ssRNA or viral RNA treatment and activate the IFN response.
      References
      Product Information
      FormatPurified
      Control
      • Hyperplastic colorectal carcinoma tissue
      PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-NOD2 Antibody, clone 2D9 is a Mouse Monoclonal Antibody for detection of NOD2 also known as NOD-like receptor C2 & has been validated in IHC, WB & IP.
      Key Applications
      • Immunohistochemistry
      • Western Blotting
      • Immunoprecipitation
      Biological Information
      ImmunogenHis-tagged recombinant protein corresponding to human NOD2.
      EpitopeUnknown
      Clone2D9
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityThis antibody recognizes NOD2.
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Species Reactivity NoteProven to react with human.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene is a member of the Nod1/Apaf-1 family and encodes a protein with two caspase recruitment (CARD) domains and six leucine-rich repeats (LRRs). The protein is primarily expressed in the peripheral blood leukocytes. It plays a role in the immune response to intracellular bacterial lipopolysaccharides (LPS) by recognizing the muramyl dipeptide (MDP) derived from them and activating the NFKB protein. Mutations in this gene have been associated with Crohn's disease and Blau syndrome. [provided by RefSeq].
      Gene Symbol
      • NOD2
      • ACUG
      • BLAU
      • CARD15
      • CD
      • CLR16.3
      • IBD1
      • NLRC2
      • NOD2B
      • PSORAS1
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: Induces NF-kappa-B via RICK (CARDIAK, RIP2) and IKK-gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS).

      SUBUNIT STRUCTURE: Binds to RICK by CARD-CARD interaction.

      SUBCELLULAR LOCATION: Cytoplasm.

      TISSUE SPECIFICITY: Monocytes-specific.

      INVOLVEMENT IN DISEASE: Defects in NOD2 are the cause of Blau syndrome (BS) [MIM:186580]. BS is a rare autosomal dominant disorder characterized by early-onset granulomatous arthritis, uveitis and skin rash.

      Defects in NOD2 are a cause of susceptibility to Crohn's disease (CD) [MIM:266600]. CD is a form of remitting inflammatory bowel disease (IBD). CD may involve any part of the gastrointestinal tract, but most frequently the terminal ileum and colon. Bowel inflammation is transmural and discontinuous. Crohn's disease is commonly classified as autoimmune disease.

      Defects in NOD2 are a cause of susceptibility to ulcerative colitis [MIM:191390]. It is a chronic inflammatory bowel disease. In ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers. Ulcerative colitis is commonly classified as autoimmune disease.

      Defects in NOD2 are the cause of early-onset sarcoidosis (EOS) [MIM:609464]. Sarcoidosis is a multiorganic inflammatory disease with unknown etiology, characterized by the histologic features of non-caseating epithelioid granulomas. In childhood, 2 distinct types of sarcoidosis have been described. Usually the disease is detected in older children by chest radiography and the clinical manifestations are characterized by a classical triad of lung, lymph node, and eye involvement, similar to those in adults. In contrast, early-onset sarcoidosis (EOS), which usually appears in those younger than 4 years of age, is quite rare and has a distinct triad of skin, joint, and eye disorders, without apparent pulmonary involvement. Compared with an asymptomatic and sometimes naturally disappearing course of the disease in older children, EOS is progressive and in many cases causes severe complications, such as blindness, joint destruction, and visceral involvement.

      SEQUENCE SIMLARITIES: Contains 2 CARD domains.

      Contains 6 LRR (leucine-rich) repeats.

      Contains 1 NACHT domain.
      Molecular Weight~110 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceImmunohistochemistry Analysis: A 1:25 dilution of this antibody detected NOD2 in hyperplastic colorectal carcinoma tissue.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      04-145 04053252363719

      Documentation

      Anti-NOD2 Antibody, clone 2D9 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-NOD2 Antibody, clone 2D9 Certificates of Analysis

      TitleLot Number
      Anti-NOD2, clone 2D9 - 2427492 2427492
      Anti-NOD2, clone 2D9 - 1995596 1995596
      Anti-NOD2, clone 2D9 - 2080298 2080298
      Anti-NOD2, clone 2D9 - 2224467 2224467
      Anti-NOD2, clone 2D9 - 2502251 2502251
      Anti-NOD2, clone 2D9 - 2532229 2532229
      Anti-NOD2, clone 2D9 - 3206401 3206401
      Anti-NOD2, clone 2D9 - 3305910 3305910
      Anti-NOD2, clone 2D9 - 3507869 3507869
      Anti-NOD2, clone 2D9 - 3607160 3607160
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