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AB10614 Anti-PSMA (CT) Antibody

Anti-PSMA (C-Terminal) Antibody detects level of PSMA (C-Terminal) & has been published & validated for use in WB.

Anti-PSMA (CT) Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Apoptosis & Cancer Research Sub-Category: Tumor Markers Gene Symbol: PSMA1, MGC22853, MGC14751, PROS30, HC2, PROS-30, MGC1667, MGC21459, PSC2, MGC14542, MGC23915, NU, MGC14575 UniProt Number: P25786, P25787, P25788, P28066, P60900, O14818
AB10614
100 µg  
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      Overview

      Replacement Information
      Replacement InformationMABN1035 is the recommended replacement for Discontinued catalog number AB10614

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBRbPurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB10614
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-PSMA (CT) Antibody
      Alternate Names
      • Prostate Specific Membrane Antigen
      Background InformationPSMA (prostate specific membrane antigen) is a type II, integral membrane glycoprotein, composed of a 19 amino acid intracellular domain containing the N-terminus, a 24 amino acid transmembrane region, and a 707 amino acid extracellular C-terminal domain. The PSMA gene has been cloned and sequenced, and has been localized to chromosome 11q. PSMA is highly expressed in prostate secretory-acinar epithelium, in some benign extraprostatic epithelial cells from breast, duodenum, and kidney tissues, and in prostate cancer. On the basis of its highly prostate-specific nature, PSMA has been used as a prostate cancer marker antigen and diagnostic target for prostate cancer detection. Recently, evidence of limited and specific endothelial PSMA expression has been discovered: the neovasculature of a wide variety of malignant neoplasms (lung, colon, breast, etc.) demonstrates PSMA expression. This finding suggests that PSMA may be an effective target for monoclonal antibody-based anti-neovasculature therapy. This may be particularly true for antibodies directed against epitopes within the C-terminal region of PSMA, based on the high degree of accessibility for antibody binding due to the extracellular location of this domain. PSMA has also been identified in the human nervous system. Based on activity, immunoreactivity, and mRNA sequence comparison with one form of NAALADase, a neuropeptide that may modulate glutaminergic transmission in the nervous system, PSMA was found to be indistinguishable from NAALADase derived from human cerebellar cell isolates. Therefore, the form of NAALADase also known as PSMA is expressed in brain, where it makes up a significant fraction of brain NAALADase activity.
      References
      Product Information
      FormatPurified
      PresentationThis polyclonal antibody is supplied in 400 μL of phosphate buffered saline (PBS), pH 7.4, containing 0.05% sodium azide (NaN3).
      Applications
      ApplicationAnti-PSMA (C-Terminal) Antibody detects level of PSMA (C-Terminal) & has been published & validated for use in WB.
      Key Applications
      • Western Blotting
      Application NotesWestern Blotting: 1-3 μg/mL
      Biological Information
      ImmunogenA synthetic peptide derived from the C-terminal region of human PSMA.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityRecognizes PSMA (C-Terminal).
      Species Reactivity
      • Human
      Species Reactivity NoteHuman (positive controls: LNCaP FGC cells, prostate cancer tissues)
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. A pseudogene has been identified on the Y chromosome.
      Gene Symbol
      • PSMA1
      • MGC22853
      • MGC14751
      • PROS30
      • HC2
      • PROS-30
      • MGC1667
      • MGC21459
      • PSC2
      • MGC14542
      • MGC23915
      • NU
      • MGC14575
      Purification MethodImmunoAffinity Purified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P60900 # The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
      SIZE: 246 amino acids; 27399 Da
      SUBUNIT: The proteasome is composed of at least 15 non identical subunits which form a highly ordered ring-shaped structure.
      SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
      SIMILARITY: SwissProt: P60900 ## Belongs to the peptidase T1A family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsFreeze -20°C.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      AB10614 04053252332975

      Documentation

      References

      Reference overviewPub Med ID
      Five different anti-prostate-specific membrane antigen (PSMA) antibodies confirm PSMA expression in tumor-associated neovasculature
      Chang, S S, et al
      Cancer Res, 59:3192-8 (1999)  1999

      		10397265 10397265
      Isolation and characterization of monoclonal antibodies specific for the extracellular domain of prostate specific membrane antigen
      Murphy, G P, et al
      J Urol, 160:2396-401 (1998)  1998

      		9817391 9817391