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MABF949-25UG Anti-Rabies Virus Antibody, clone 1112-1

Anti-Rabies Virus, clone 1112-1, Cat. No. MABF949, is a mouse monoclonal antibody that detects glycoprotein of strain ERA rabbies virus. It has been tested for use in Flow Cytometry and for Neutralizing.

Anti-Rabies Virus Antibody, clone 1112-1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Inflammation & Immunology UniProt Number: P03524
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MABF949-25UG
25 μg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      VirusFC, NEUTMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABF949-25UG
      DescriptionAnti-Rabies Virus Antibody, clone 1112-1
      Background InformationGlycoprotein of Evelyn Rokitniki Abelseth (ERA) SAD derived Rabies virus strain (UniProt: P03524) is encoded by the G gene. It belongs to the lyssavirus glycoprotein of the Rhabdoviridae family. This glycoprotein is a single pass type I virion membrane protein that helps in attaching the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. It has been shown that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (N-CAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and facilitate rabies virus entry into cells. Arg352 of Glycoprotein is highly involved in rabies virus pathogenicity and mutation at this site dramatically attenuates the virus.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal antibody IgG1 in PBS without azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Rabies Virus, clone 1112-1, Cat. No. MABF949, is a mouse monoclonal antibody that detects glycoprotein of strain ERA rabbies virus. It has been tested for use in Flow Cytometry and for Neutralizing.
      Key Applications
      • Flow Cytometry
      • Neutralizing
      Application NotesNeutralizing Analysis:  A representative lot neutralized Rabies Virus (Bunschoten, H., et. al. (1989). J Gen Virol. 70 ( Pt 2):291-8; Dietzchold, B., et. al. (1992). Proc Natl Acad Sci USA. 89(15):7252-6; Muller, T., et. al. (2009). PLoS Neql Trop Dis. 3(11):e542; Schumacher, C.L., et. al. (1989). J Clin Invest. 84(3):971-5).
      Biological Information
      ImmunogenGlycoprotein of ERA (Evelyn Rokitniki Abelseth) strain Rabies virus.
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone 1112-1 detects glycoprotein of ERA strain of rabies virus in L929 cells that express rabies protein.
      IsotypeIgG1
      Species Reactivity
      • Virus
      Species Reactivity NoteRabies Virus.
      Antibody TypeMonoclonal Antibody
      Purification MethodProtein G purified
      UniProt Number
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Flow Cytometry in L929 expressing rabies protein. Flow Cytometry Analysis: 1 µg of this antibody detected Rabies Virus in one million L929 cells expressing rabies protein.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size25 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABF949-25UG 04054839421068