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SCC221 DM6 Human Melanoma Cell Line

DM6 human melanoma cell line is an established model for immunotherapy and chemoresistance studies.

SCC221
≥1X10⁶ cells/vial   
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      Overview

      Replacement Information
      Description
      Catalogue NumberSCC221
      DescriptionDM6 Human Melanoma Cell Line
      OverviewThe DM6 human melanoma cell line is an established model for immunotherapy and chemoresistance. DM6 human melanoma cells harbor the melanoma driver mutation BRAF V600E and express the melanoma markers gp100 and MelanA (2). DM6 human melanoma cells express HLA-A2 antigen and are competent to induce T-cell cytotoxic response (3).The antigenic expression profile of this cell line has contributed to its utilization as a viable model for evaluating targeted cancer immunotherapy (4). DM6 melanoma cells are extremely resistant to the common first-line chemotherapy for malignant melanoma (5). The unique features of the DM6 human melanoma cell line make it a system with high clinical relevance.

      Source:
      The DM6 human melanoma cell line was derived from surgically excised lymph nodes dispersed into single cell suspensions (2).
      Alternate Names
      • DM006
      • Duke Melanoma 6
      Background InformationAlthough cases of malignant melanoma show a high survival rate when treated early, patients with later stages of the disease and chemotherapy-resistant forms have a poor prognosis (1). Relevant cellular models of human chemoresistant melanoma are of great importance for understanding mechanisms of resistance and in aiding the development of effective new treatments, especially targeted immunotherapies.

      References:
      1. Clin Cancer Res. 2006; 12(7 Pt 2): 2312s-2319s.
      2. Cancer Immunol Immunother. 2000; 48(12): 661-672.
      3. Cancer Res. 1990; 50(3): 492-498.
      4. Sci Transl Med. 2017; 9(408): eaan4220
      5. Clin Cancer Res. 2009; 15(2): 502-510.
      References
      Product Information
      Applications
      ApplicationDM6 human melanoma cell line is an established model for immunotherapy and chemoresistance studies.
      Key Applications
      • Cell Culture
      Application NotesThis product is intended for sale and sold solely to academic institutions for internal academic research use per the terms of the “Academic Use Agreement” as detailed in the product documentation. For information regarding any other use, please contact licensing@emdmillipore.com.
      Biological Information
      Cell Line Type
      • Cancer Cells
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assurance• Each vial contains ≥ 1X10⁶ viable cells.
      • Cells are tested negative for infectious diseases by a Human Essential CLEAR panel by Charles River Animal Diagnostic Services.
      • Cells are verified to be of human origin and negative for inter-species contamination from rat, mouse, chinese hamster, Golden Syrian hamster, and non-human primate (NHP) as assessed by a Contamination CLEAR panel by Charles River Animal Diagnostic Services.
      • Cells are negative for mycoplasma contamination.
      • Each lot of cells is genotyped by STR analysis to verify the unique identity of the cell line.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.
      Packaging Information
      Material Size≥1X10⁶ cells/vial
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      SCC221 04061841074922

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