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324759 Elastase Inhibitor IV - CAS 127373-66-4 - Calbiochem

The Elastase Inhibitor IV, also referenced under CAS 127373-66-4, controls the biological activity of Elastase. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-(o-(p-Pivaloyloxybenzene)sulfonylaminobenzoyl)glycine, N-(2-(4-(2,2-Dimethylpropionyloxy)phenylsulfonylamino)benzoyl)aminoacetic acid

Primary Target: Neutrophil elastase
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324759
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
127373-66-4C₂₀H₂₂N₂O₇S

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      Description
      OverviewA cell-permeable sulfanilide compound that acts as a potent, substrate-competitive, and highly specific inhibitor of neutrophil elastase (IC50 = 19-49 nM in rat, rabbit, hamster, human, and mouse leukocyte elastase). Displays >100-fold greater selectivity over pancreas elastase (IC50 = 5.6 µM). Does not inhibit trypsin, thrombin, plasmin, kallikrein, chymotrypsin, and cathepsin G even at concentrations as high as 100 µM. Effectively suppresses human neutrophil elastase-induced lung hemorrhage and skin capillary permeability in vivo. Also reported to inhibit mast cell Stat6-protease.
      Catalogue Number324759
      Brand Family Calbiochem®
      SynonymsN-(o-(p-Pivaloyloxybenzene)sulfonylaminobenzoyl)glycine, N-(2-(4-(2,2-Dimethylpropionyloxy)phenylsulfonylamino)benzoyl)aminoacetic acid
      References
      ReferencesSuzuki, K., et al. 2003. Biochem. Biophys. Res. Commun. 309, 768.
      Kawabata, K., et al. 1991. Biochem. Biophys. Res. Commun. 177, 814.
      Product Information
      CAS number127373-66-4
      ATP CompetitiveN
      FormWhite to off-white solid
      Hill FormulaC₂₀H₂₂N₂O₇S
      Chemical formulaC₂₀H₂₂N₂O₇S
      HS Code2935 90 99
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetNeutrophil elastase
      Primary Target IC<sub>50</sub>19-49 nM in rat, rabbit, hamster, human, and mouse leukocyte elastase
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      324759-1MG 04055977216080

      Documentation

      Elastase Inhibitor IV - CAS 127373-66-4 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Elastase Inhibitor IV - CAS 127373-66-4 - Calbiochem Certificates of Analysis

      TitleLot Number
      324759

      References

      Reference overview
      Suzuki, K., et al. 2003. Biochem. Biophys. Res. Commun. 309, 768.
      Kawabata, K., et al. 1991. Biochem. Biophys. Res. Commun. 177, 814.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision03-April-2008 RFH
      SynonymsN-(o-(p-Pivaloyloxybenzene)sulfonylaminobenzoyl)glycine, N-(2-(4-(2,2-Dimethylpropionyloxy)phenylsulfonylamino)benzoyl)aminoacetic acid
      DescriptionA cell-permeable, potent, substrate-competitive, and highly specific inhibitor of neutrophil elastase (IC50 = 19-49 nM using rat, rabbit, hamster, human, and mouse leukocyte elastase). Displays about 100-fold greater selectivity over pancreatic elastase (IC50 = 5.6 µM) and is inactive against trypsin, thrombin, plasmin, kallikrein, chymotrypsin, and cathepsin G even at concentrations as high as 100 µM. Effectively suppresses human neutrophil elastase-induced lung hemorrhage and skin capillary permeability in vivo. Also reported to inhibit mast cell Stat6-protease.
      FormWhite to off-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number127373-66-4
      Chemical formulaC₂₀H₂₂N₂O₇S
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesSuzuki, K., et al. 2003. Biochem. Biophys. Res. Commun. 309, 768.
      Kawabata, K., et al. 1991. Biochem. Biophys. Res. Commun. 177, 814.