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345670 Galanthamine, Hydrobromide - CAS 69353-21-5 - Calbiochem

A competitive and reversible inhibitor of acetylcholinesterase.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Nivalin, HBr

Primary Target: Acetylcholinesterase
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      69353-21-5C₁₇H₂₁NO₃ · HBr
      Description
      OverviewA competitive and reversible inhibitor of acetylcholinesterase. Antimyasthenic agent. Can partially reverse the effects of scopolamine-induced amnesia in rats. Reported to improve learning and short-term memory in animal models.
      Catalogue Number345670
      Brand Family Calbiochem®
      SynonymsNivalin, HBr
      References
      ReferencesPilger, C., et al. 2001. J. Mol. Graph. Model 19, 288.
      Iliev, A., et al. 1999. Methods Find. Exp. Clin. Pharmacol. 21, 297.
      Southan, G.J., et al. 1996. Br. J. Pharmacol. 117, 619.
      Mutafova-Yambolieva, V.N., et al. 1993. Gen. Pharmacol. 24, 1253.
      Product Information
      CAS number69353-21-5
      ATP CompetitiveY
      FormWhite solid
      Hill FormulaC₁₇H₂₁NO₃ · HBr
      Chemical formulaC₁₇H₂₁NO₃ · HBr
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetAcetylcholinesterase
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSDF8075000
      Safety Information
      R PhraseR: 25

      Toxic if swallowed.
      S PhraseS: 22-36/37/39-45

      Do not breathe dust.
      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +2°C to +8°C
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      345670 0

      Documentation

      Galanthamine, Hydrobromide - CAS 69353-21-5 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Galanthamine, Hydrobromide - CAS 69353-21-5 - Calbiochem Certificates of Analysis

      TitleLot Number
      345670

      References

      Reference overview
      Pilger, C., et al. 2001. J. Mol. Graph. Model 19, 288.
      Iliev, A., et al. 1999. Methods Find. Exp. Clin. Pharmacol. 21, 297.
      Southan, G.J., et al. 1996. Br. J. Pharmacol. 117, 619.
      Mutafova-Yambolieva, V.N., et al. 1993. Gen. Pharmacol. 24, 1253.

      Brochure

      Title
      Alzheimer's Disease Brochure & Technical Guide
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision30-March-2010 RFH
      SynonymsNivalin, HBr
      DescriptionCholinesterase antagonist. Antimyasthenic agent. Can partially reverse the effects of scopolamine-induced amnesia in rats.
      FormWhite solid
      CAS number69353-21-5
      RTECSDF8075000
      Chemical formulaC₁₇H₂₁NO₃ · HBr
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml), Ethanol (1 mg/ml) or H₂O (1 mg/ml)
      Storage Protect from moisture
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Toxic
      Merck USA index14, 4340
      ReferencesPilger, C., et al. 2001. J. Mol. Graph. Model 19, 288.
      Iliev, A., et al. 1999. Methods Find. Exp. Clin. Pharmacol. 21, 297.
      Southan, G.J., et al. 1996. Br. J. Pharmacol. 117, 619.
      Mutafova-Yambolieva, V.N., et al. 1993. Gen. Pharmacol. 24, 1253.